Proof of Concept Percutaneous Treatment System to Enable Fast and Finely Controlled Ablation of Biological Tissue

Overview

Journal Med Biol Eng Comput

Publisher Springer

Specialties Biomedical Engineering
Medical Informatics

Date 2007 Apr 20

PMID 17443357

Citations 2

Authors

C P Hancock

S Chaudhry

P Wall

A M Goodman

Affiliations

Soon will be listed here.

Abstract

A prototype system has been developed for producing controllable ablation of spherical lesions with a diameter of up to 2 cm. The system is based on a solid-state energy source operating in the super high frequency (SHF is defined as being a frequency of between 3 and 30 GHz) region of the electromagnetic spectrum. Results obtained from preliminary tissue testing, performed on morbid tissue samples prepared in a laboratory environment, show repeatability in terms of shape and size of ablation, and demonstrate the ability to produce controlled ablation in morbid liver and kidney models.

Citing Articles

On the effects of 30.5 GHz sinusoidal wave exposure on glioblastoma organoids.

Rampazzo E, Persano L, Karim N, Hodgking G, Pinto R, Casciati A Front Oncol. 2024; 14:1307516.

PMID: 38884089 PMC: 11176452. DOI: 10.3389/fonc.2024.1307516.

Interventional navigation systems for treatment of unresectable liver tumor.

Phee S, Yang K Med Biol Eng Comput. 2009; 48(2):103-11.

PMID: 20041312 DOI: 10.1007/s11517-009-0568-3.

References

Solbiati L, Goldberg S, Ierace T, Livraghi T, Meloni F, Dellanoce M . Hepatic metastases: percutaneous radio-frequency ablation with cooled-tip electrodes. Radiology. 1997; 205(2):367-73. DOI: 10.1148/radiology.205.2.9356616. View

Livraghi T, Goldberg S, Monti F, Bizzini A, Lazzaroni S, Meloni F . Saline-enhanced radio-frequency tissue ablation in the treatment of liver metastases. Radiology. 1997; 202(1):205-10. DOI: 10.1148/radiology.202.1.8988212. View

Erce C, Parks R . Interstitial ablative techniques for hepatic tumours. Br J Surg. 2003; 90(3):272-89. DOI: 10.1002/bjs.4091. View

Heisterkamp J, van Hillegersberg R, Ijzermans J . Interstitial laser coagulation for hepatic tumours. Br J Surg. 1999; 86(3):293-304. DOI: 10.1046/j.1365-2168.1999.01059.x. View

Wright A, Lee Jr F, Mahvi D . Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis. Ann Surg Oncol. 2003; 10(3):275-83. DOI: 10.1245/aso.2003.03.045. View

Strickland A, Clegg P, Cronin N, Swift B, Festing M, West K . Experimental study of large-volume microwave ablation in the liver. Br J Surg. 2002; 89(8):1003-7. DOI: 10.1046/j.1365-2168.2002.02155.x. View

Chen J, Moriarty J, Derbyshire J, Peters R, Trachtenberg J, Bell S . Prostate cancer: MR imaging and thermometry during microwave thermal ablation-initial experience. Radiology. 2000; 214(1):290-7. DOI: 10.1148/radiology.214.1.r00ja06290. View

Neeman Z, Wood B . Radiofrequency ablation beyond the liver. Tech Vasc Interv Radiol. 2003; 5(3):156-63. PMC: 2408945. DOI: 10.1053/tvir.2002.36419. View

Shock S, Meredith K, Warner T, Sampson L, Wright A, Winter 3rd T . Microwave ablation with loop antenna: in vivo porcine liver model. Radiology. 2004; 231(1):143-9. DOI: 10.1148/radiol.2311021342. View

10.

Vargas H, Dooley W, Gardner R, Gonzalez K, Venegas R, Heywang-Kobrunner S . Focused microwave phased array thermotherapy for ablation of early-stage breast cancer: results of thermal dose escalation. Ann Surg Oncol. 2004; 11(2):139-46. DOI: 10.1245/aso.2004.03.059. View

11.

Haemmerich D, Lee Jr F, Schutt D, Sampson L, Webster J, Fine J . Large-volume radiofrequency ablation of ex vivo bovine liver with multiple cooled cluster electrodes. Radiology. 2004; 234(2):563-8. DOI: 10.1148/radiol.2342031122. View

12.

Garcea G, Lloyd T, Aylott C, Maddern G, Berry D . The emergent role of focal liver ablation techniques in the treatment of primary and secondary liver tumours. Eur J Cancer. 2003; 39(15):2150-64. DOI: 10.1016/s0959-8049(03)00553-7. View

13.

Goldberg S, Solbiati L, Hahn P, Cosman E, Conrad J, Fogle R . Large-volume tissue ablation with radio frequency by using a clustered, internally cooled electrode technique: laboratory and clinical experience in liver metastases. Radiology. 1998; 209(2):371-9. DOI: 10.1148/radiology.209.2.9807561. View

14.

Skinner M, Iizuka M, Kolios M, Sherar M . A theoretical comparison of energy sources--microwave, ultrasound and laser--for interstitial thermal therapy. Phys Med Biol. 1998; 43(12):3535-47. DOI: 10.1088/0031-9155/43/12/011. View

15.

Wright A, Sampson L, Warner T, Mahvi D, Lee Jr F . Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology. 2005; 236(1):132-9. DOI: 10.1148/radiol.2361031249. View