Patterning of Frontal Cortex Subdivisions by Fgf17

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2007 Apr 20

PMID 17442747

Citations 85

Authors

Jeremy A Cholfin

John L R Rubenstein

Affiliations

Soon will be listed here.

Abstract

The frontal cortex (FC) is the seat of higher cognition. The genetic mechanisms that control formation of the functionally distinct subdivisions of the FC are unknown. Using a set of gene expression markers that distinguish subdivisions of the newborn mouse FC, we show that loss of Fgf17 selectively reduces the size of the dorsal FC whereas ventral/orbital FC appears normal. These changes are complemented by a rostral shift of sensory cortical areas. Thus, Fgf17 functions similar to Fgf8 in patterning the overall neocortical map but has a more selective role in regulating the properties of the dorsal but not ventral FC.

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