Activated CD34-derived Langerhans Cells Mediate Transinfection with Human Immunodeficiency Virus

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2007 Apr 20

PMID 17442711

Citations 61

Authors

Kelly M Fahrbach

Sheila M Barry

Seyoum Ayehunie

Sarah Lamore

Mitchell Klausner

Thomas J Hope

Affiliations

Soon will be listed here.

Abstract

Langerhans cells (LCs) are a subset of dendritic cells (DCs) that reside within epidermal and mucosal tissue. Because of their location, LCs are potentially the first cells to encounter human immunodeficiency virus (HIV) during sexual transmission. We report that LCs purified from CD34(+)-derived DCs can facilitate the transinfection of target cells but only after activation. Virions were observed in an intracellular compartment that contains several tetraspanins, in addition to the unique LC markers langerin and CD1a. This reveals that the trafficking of HIV within LCs is reminiscent of that which occurs in mature monocyte-derived DCs and that it varies with the activation state of the cell. The observation that activated LCs can mediate transinfection suggests a potential role for these cells in the known increase in HIV transmission associated with sexually transmitted infections that would cause inflammation of the genital lining.

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References

Popov S, Chenine A, Gruber A, Li P, Ruprecht R . Long-term productive human immunodeficiency virus infection of CD1a-sorted myeloid dendritic cells. J Virol. 2004; 79(1):602-8. PMC: 538684. DOI: 10.1128/JVI.79.1.602-608.2005. View

Reece J, Handley A, Anstee E, Morrison W, Crowe S, Cameron P . HIV-1 selection by epidermal dendritic cells during transmission across human skin. J Exp Med. 1998; 187(10):1623-31. PMC: 2212292. DOI: 10.1084/jem.187.10.1623. View

Berthier-Vergnes O, Bermond F, Flacher V, Massacrier C, Schmitt D, Peguet-Navarro J . TNF-alpha enhances phenotypic and functional maturation of human epidermal Langerhans cells and induces IL-12 p40 and IP-10/CXCL-10 production. FEBS Lett. 2005; 579(17):3660-8. DOI: 10.1016/j.febslet.2005.04.087. View

Villadangos J, Heath W . Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: limitations of the Langerhans cells paradigm. Semin Immunol. 2005; 17(4):262-72. DOI: 10.1016/j.smim.2005.05.015. View

Kawamura T, Kurtz S, Blauvelt A, Shimada S . The role of Langerhans cells in the sexual transmission of HIV. J Dermatol Sci. 2005; 40(3):147-55. DOI: 10.1016/j.jdermsci.2005.08.009. View

Wiley R, Gummuluru S . Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection. Proc Natl Acad Sci U S A. 2006; 103(3):738-43. PMC: 1334656. DOI: 10.1073/pnas.0507995103. View

Boggiano C, Manel N, Littman D . Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN. J Virol. 2006; 81(5):2519-23. PMC: 1865951. DOI: 10.1128/JVI.01661-06. View

Sabet S, Ochoa M, Sieling P, Rea T, Modlin R . Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion. Immunology. 2006; 120(3):354-61. PMC: 2265884. DOI: 10.1111/j.1365-2567.2006.02510.x. View

de Witte L, Nabatov A, Pion M, Fluitsma D, de Jong M, de Gruijl T . Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. Nat Med. 2007; 13(3):367-71. DOI: 10.1038/nm1541. View

10.

Campbell E, Perez O, Melar M, Hope T . Labeling HIV-1 virions with two fluorescent proteins allows identification of virions that have productively entered the target cell. Virology. 2006; 360(2):286-93. PMC: 1885464. DOI: 10.1016/j.virol.2006.10.025. View

11.

Cavrois M, Neidleman J, Kreisberg J, Greene W . In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions. PLoS Pathog. 2007; 3(1):e4. PMC: 1779297. DOI: 10.1371/journal.ppat.0030004. View

12.

Blauvelt A, Glushakova S, Margolis L . HIV-infected human Langerhans cells transmit infection to human lymphoid tissue ex vivo. AIDS. 2000; 14(6):647-51. DOI: 10.1097/00002030-200004140-00003. View

13.

Sugita M, Peters P, Brenner M . Pathways for lipid antigen presentation by CD1 molecules: nowhere for intracellular pathogens to hide. Traffic. 2001; 1(4):295-300. DOI: 10.1034/j.1600-0854.2000.010401.x. View

14.

Turville S, Arthos J, Donald K, Lynch G, Naif H, Clark G . HIV gp120 receptors on human dendritic cells. Blood. 2001; 98(8):2482-8. DOI: 10.1182/blood.v98.8.2482. View

15.

Mc Dermott R, Ziylan U, Spehner D, Bausinger H, Lipsker D, Mommaas M . Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans cells, which form where Langerin accumulates. Mol Biol Cell. 2002; 13(1):317-35. PMC: 65091. DOI: 10.1091/mbc.01-06-0300. View

16.

Kwon D, Gregorio G, Bitton N, Hendrickson W, Littman D . DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity. 2002; 16(1):135-44. DOI: 10.1016/s1074-7613(02)00259-5. View

17.

Frank I, Pope M . The enigma of dendritic cell-immunodeficiency virus interplay. Curr Mol Med. 2002; 2(3):229-48. DOI: 10.2174/1566524024605716. View

18.

Sanders R, de Jong E, Baldwin C, Schuitemaker J, Kapsenberg M, Berkhout B . Differential transmission of human immunodeficiency virus type 1 by distinct subsets of effector dendritic cells. J Virol. 2002; 76(15):7812-21. PMC: 136398. DOI: 10.1128/jvi.76.15.7812-7821.2002. View

19.

Turville S, Cameron P, Handley A, Lin G, Pohlmann S, Doms R . Diversity of receptors binding HIV on dendritic cell subsets. Nat Immunol. 2002; 3(10):975-83. DOI: 10.1038/ni841. View

20.

McDonald D, Vodicka M, Lucero G, Svitkina T, Borisy G, Emerman M . Visualization of the intracellular behavior of HIV in living cells. J Cell Biol. 2002; 159(3):441-52. PMC: 2173076. DOI: 10.1083/jcb.200203150. View