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Sulfasalazine-induced Pericarditis in a Patient with Ulcerative Colitis Without Recurrence when Switching to Mesalazine

Overview
Journal Int J Colorectal Dis
Specialties Gastroenterology
General Surgery
Date 2007 Apr 19
PMID 17440739
Citations 7
Authors
Serge Perrot
Elisabeth Aslangul
Tali Szwebel
Houdha Gadhoum
Sophie Romnicianu
Claire Le Jeunne
Affiliations
Soon will be listed here.
Abstract

Introduction: Pericarditis is rarely reported in inflammatory bowel disease. Besides its common causes, pericarditis could be related to ulcerative colitis flare or to 5-aminosalicylic acid (5-ASA) treatment.

Case Report: We report the case of a patient in whom fever, weight loss and pericarditis developed after 16 years of treatment with sulfasalazine for ulcerative colitis, after increasing the daily dosage from 1 to 3 g.

Discussion: The patient recovered after treatment discontinuation and did not exhibit any recurrence of pericarditis when treatment with mesalazine was introduced.

Conclusion: In conclusion, if pericarditis occurs in ulcerative colitis patients treated with 5-ASA compounds, the treatment should be considered as a possible cause, even after an increase of the dosage. In this case, discontinuation of the treatment and cautious switch to another 5-ASA compound should be tested.

Citing Articles

Recurrent Pericarditis: A Rare Adverse Effect of Mesalamine.

Karki P, Kunwar A, Sharma N, Dogra M Cureus. 2023; 15(1):e33661.

PMID: 36788872 PMC: 9915855. DOI: 10.7759/cureus.33661.

Cardiovascular Manifestations in Inflammatory Bowel Disease: A Systematic Review of the Pathogenesis and Management of Pericarditis.

Patel R, Rohit Reddy S, Llukmani A, Hashim A, Haddad D, Patel D Cureus. 2021; 13(3):e14010.

PMID: 33884251 PMC: 8054944. DOI: 10.7759/cureus.14010.

Mesalamine-Induced Myopericarditis: A Case Report and Literature Review.

Taha M, Abdalla A, Al-Khafaji J, Malik S Cardiol Res. 2019; 10(1):59-62.

PMID: 30834061 PMC: 6396800. DOI: 10.14740/cr820.

5-Aminosalicylic Acid-Associated Myocarditis and Pericarditis: A Narrative Review.

Brown G Can J Hosp Pharm. 2017; 69(6):466-472.

PMID: 28123193 PMC: 5242279.

Mesalamine-induced refractory fever and progressive increase in creatinine level and leukocyte count in a patient with enteropathic arthritis.

Isik M Eur J Rheumatol. 2016; 1(3):129-130.

PMID: 27708895 PMC: 5042224. DOI: 10.5152/eurjrheumatol.2014.029.

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