Memory CD4 T Cells Enhance Primary CD8 T-cell Responses

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2007 Apr 18

PMID 17438031

Citations 25

Authors

Connie M Krawczyk

Hao Shen

Edward J Pearce

Affiliations

Soon will be listed here.

Abstract

CD4 T-cell help is required for optimal memory CD8 T-cell responses. We have found that engaging preexisting CD4 Th1, but not Th2, memory cells at the time of CD8 T-cell priming results in increased CD8 effector responses to both bacterial and viral pathogens. The enhanced responses are characterized by increased numbers of cytokine-producing, antigen-specific cells. These findings suggest that engaging endogenous memory Th1 cells may increase cellular responses in an immunotherapy or vaccination setting.

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