Alpha 2.0
Login Register
» Articles » PMID: 17435969

Pathology of Vogt-Koyanagi-Harada Disease

Overview
Journal Int Ophthalmol
Specialty Ophthalmology
Date 2007 Apr 17
PMID 17435969
Citations 49
Authors
Narsing A Rao
Affiliations
Soon will be listed here.
Abstract

Typical histopathologic features of Vogt-Koyanagi-Harada disease (VKH) include granulomatous panuveitis with preservation of the choriocapillaris and exudative retinal detachment. In the chronic stage of the disease, however, histologic changes consist of nongranulomatous uveitis followed, in the chronic recurrent stage, by granulomatous uveitis and involvement of the choriocapillaris. In chronic VKH the peripheral fundus scars are not Dalén-Fuchs nodules; they are, instead, indicative of focal chorioretinal atrophy with loss of retinal pigment epithelium.

Citing Articles

Compositional variation in eye-infiltrating immune cells distinguishes human uveitis subtypes.

Concepcion C, Xia Y, Korshunova Y, Bligard G, Taylor A, Paley M iScience. 2025; 28(3):111928.

PMID: 40060903 PMC: 11889669. DOI: 10.1016/j.isci.2025.111928.

Early Changes in Ocular Biomarkers in Patients with Vogt-Koyanagi-Harada Disease after Pulse Steroid Therapy.

Muto T, Kawaguchi S, Kusuda S, Misu K, Sakamoto M, Machida S Ophthalmologica. 2024; 248(1):40-53.

PMID: 39571547 PMC: 11901411. DOI: 10.1159/000542724.

Vogt-Koyanagi-Harada Disease: A Narrative Review.

Tayal A, Daigavane S, Gupta N Cureus. 2024; 16(4):e58867.

PMID: 38800227 PMC: 11116741. DOI: 10.7759/cureus.58867.

Comparisons of choroidal blood flow velocity between initial-onset acute uveitis associated with Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy.

Abu El-Asrar A, Albloushi A, Abouammoh M, Alzubaidi A, Gikandi P, Al Faran A Eye (Lond). 2023; 38(7):1269-1275.

PMID: 38129662 PMC: 11076456. DOI: 10.1038/s41433-023-02879-0.

Correlation Between Hyperreflective Foci in the Choroid and Choroidal Discoloration in Vogt-Koyanagi-Harada Disease.

Kim Y, Togloom A, Oh J Invest Ophthalmol Vis Sci. 2022; 63(9):27.

PMID: 36006654 PMC: 9428358. DOI: 10.1167/iovs.63.9.27.

References
1.
Inomata H, RAO N . Depigmented atrophic lesions in sunset glow fundi of Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2001; 131(5):607-14. DOI: 10.1016/s0002-9394(00)00851-5. View
2.
Yamaki K, Gocho K, Hayakawa K, Kondo I, Sakuragi S . Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease. J Immunol. 2000; 165(12):7323-9. DOI: 10.4049/jimmunol.165.12.7323. View
3.
Perry H, Font R . Clinical and histopathologic observations in severe Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1977; 83(2):242-54. DOI: 10.1016/0002-9394(77)90623-7. View
4.
Font R, FINE B, Messmer E, Rowsey J . Light and electron microscopic study of Dalén-Fuchs nodules in sympathetic ophthalmia. Ophthalmology. 1983; 90(1):66-75. DOI: 10.1016/s0161-6420(83)34595-4. View
5.
Jakobiec F, Marboe C, Knowles 2nd D, Iwamoto T, Harrison W, Chang S . Human sympathetic ophthalmia. An analysis of the inflammatory infiltrate by hybridoma-monoclonal antibodies, immunochemistry, and correlative electron microscopy. Ophthalmology. 1983; 90(1):76-95. DOI: 10.1016/s0161-6420(83)34602-9. View