Gastrointestinal Manifestations in Patients with Common Variable Immunodeficiency

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2007 Apr 14

PMID 17431775

Citations 41

Authors

Ahmad Khodadad

Asghar Aghamohammadi

Nima Parvaneh

Nima Rezaei

Fatemeh Mahjoob

Mohammad Bashashati

Masoud Movahedi

Mohammad Reza Fazlollahi

Fariborz Zandieh

Zahra Roohi

Sina Abdollahzade

Ali Salavati

Ali Kouhi

Bahram Talebpour

Nasser Ebrahimi Daryani

Affiliations

Soon will be listed here.

Abstract

This study focuses on endoscopic and pathologic alterations of gastrointestinal (GI) disorders of Iranian patients with common variable immunodeficiency (CVID). Nineteen of 39 CVID patients (48%) had GI complaints. The most common symptom was chronic diarrhea (28%). In endoscopic examination of small intestines, 15 patients had no abnormal finding. Duodenal biopsy revealed villous atrophy in eight and nodular lymphoid hyperplasia in three patients. There was no statistically significant difference between patients with and patients without duodenal villous atrophy regarding the presence of chronic diarrhea, anemia, and absolute CD4+T cells. In three patients, biopsies of the colon showed chronic noncrypt-destructive colitis. GI problems pose a high morbidity to CVID patients and are second only to respiratory complications. CVID patients are at increased risk of infectious and inflammatory conditions in the GI tract. Early diagnosis of these complications improves the quality of life and well-being of patients.

Citing Articles

The Natural History of Inflammatory Bowel Disease in Adults With Common Variable Immunodeficiency: A Case Series From a Single US Tertiary Care Center.

Jha P, Elangovan A, Chavan A, Cooper G, Katz J, Cominelli F Crohns Colitis 360. 2025; 7(1):otae062.

PMID: 39917029 PMC: 11799737. DOI: 10.1093/crocol/otae062.

Gastrointestinal Disease in Common Variable Immunodeficiency Disorder (CVID): Histological Patterns, Diagnostic Clues and Pitfalls for the Pathologist and Gastroenterologist.

Velthof L, Geldof J, Truyens M, Van Dorpe J, Ferdinande L, De Vriendt C J Clin Med. 2025; 14(2).

PMID: 39860504 PMC: 11765826. DOI: 10.3390/jcm14020497.

Endoscopic and histopathological hints on infections in patients of common variable immunodeficiency disorder with gastrointestinal symptoms.

Chen Y, You Y, Li J, Yang A, Zhou W, Li X BMC Gastroenterol. 2023; 23(1):413.

PMID: 38017379 PMC: 10683160. DOI: 10.1186/s12876-023-03052-3.

Development of a primary care screening algorithm for the early detection of patients at risk of primary antibody deficiency.

Messelink M, Berbers R, van Montfrans J, Ellerbroek P, Gladiator A, Welsing P Allergy Asthma Clin Immunol. 2023; 19(1):44.

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Liver disease accompanied by enteropathy in common variable immunodeficiency: Common pathophysiological mechanisms.

Lima F, Toledo-Barros M, Alves V, Duarte M, Takakura C, Bernardes-Silva C Front Immunol. 2022; 13:933463.

PMID: 36341360 PMC: 9632424. DOI: 10.3389/fimmu.2022.933463.

References

Strober W, Chua K . Common variable immunodeficiency. Clin Rev Allergy Immunol. 2000; 19(2):157-81. DOI: 10.1385/CRIAI:19:2:157. View

Lai Ping So A, Mayer L . Gastrointestinal manifestations of primary immunodeficiency disorders. Semin Gastrointest Dis. 1997; 8(1):22-32. View

Washington K, Stenzel T, Buckley R, Gottfried M . Gastrointestinal pathology in patients with common variable immunodeficiency and X-linked agammaglobulinemia. Am J Surg Pathol. 1996; 20(10):1240-52. DOI: 10.1097/00000478-199610000-00010. View

Hammarstrom L, Vorechovsky I, Webster D . Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin Exp Immunol. 2000; 120(2):225-31. PMC: 1905641. DOI: 10.1046/j.1365-2249.2000.01131.x. View

Sneller M . Common variable immunodeficiency. Am J Med Sci. 2001; 321(1):42-8. DOI: 10.1097/00000441-200101000-00007. View

CARPENTER H, Talley N . The importance of clinicopathological correlation in the diagnosis of inflammatory conditions of the colon: histological patterns with clinical implications. Am J Gastroenterol. 2000; 95(4):878-96. DOI: 10.1111/j.1572-0241.2000.01924.x. View

Conley M, Notarangelo L, Etzioni A . Diagnostic criteria for primary immunodeficiencies. Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies). Clin Immunol. 1999; 93(3):190-7. DOI: 10.1006/clim.1999.4799. View

Byrne M, Royston D, Patchett S . Association of common variable immunodeficiency with atypical collagenous colitis. Eur J Gastroenterol Hepatol. 2003; 15(9):1051-3. DOI: 10.1097/00042737-200309000-00019. View

Cunningham-Rundles C, Bodian C . Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol. 1999; 92(1):34-48. DOI: 10.1006/clim.1999.4725. View

10.

Webster A . Clinical and Immunological Spectrum of Common Variable Immunodeficiency (CVID). Iran J Allergy Asthma Immunol. 2007; 3(3):103-13. DOI: 03.03/ijaai.103113. View

11.

Atarod L, Raissi A, Aghamohammadi A, Farhoudi A, Khodadad A, Moin M . A review of gastrointestinal disorders in patients with primary antibody immunodeficiencies during a 10-year period (1990-2000), in children hospital medical center. Iran J Allergy Asthma Immunol. 2007; 2(2):75-9. DOI: 02.02/ijaai.7579. View

12.

Lazenby A, Yardley J, Giardiello F, Jessurun J, Bayless T . Lymphocytic ("microscopic") colitis: a comparative histopathologic study with particular reference to collagenous colitis. Hum Pathol. 1989; 20(1):18-28. DOI: 10.1016/0046-8177(89)90198-6. View

13.

Bastlein C, Burlefinger R, Holzberg E, Voeth C, Garbrecht M, OTTENJANN R . Common variable immunodeficiency syndrome and nodular lymphoid hyperplasia in the small intestine. Endoscopy. 1988; 20(5):272-5. DOI: 10.1055/s-2007-1018192. View

14.

HERMANS P, Diaz-Buxo J, Stobo J . Idiopathic late-onset immunoglobulin deficiency. Clinical observations in 50 patients. Am J Med. 1976; 61(2):221-37. DOI: 10.1016/0002-9343(76)90173-x. View

15.

Eidt S, Stolte M . Prevalence of intestinal metaplasia in Helicobacter pylori gastritis. Scand J Gastroenterol. 1994; 29(7):607-10. DOI: 10.3109/00365529409092480. View

16.

Kinlen L, Webster A, Bird A, Haile R, Peto J, Soothill J . Prospective study of cancer in patients with hypogammaglobulinaemia. Lancet. 1985; 1(8423):263-6. DOI: 10.1016/s0140-6736(85)91037-2. View

17.

McCabe R . Gastrointestinal Manifestations of Non-AIDS Immunodeficiency. Curr Treat Options Gastroenterol. 2002; 5(1):17-25. DOI: 10.1007/s11938-002-0003-4. View

18.

Teahon K, Webster A, Price A, Weston J, Bjarnason I . Studies on the enteropathy associated with primary hypogammaglobulinaemia. Gut. 1994; 35(9):1244-9. PMC: 1375701. DOI: 10.1136/gut.35.9.1244. View

19.

Craanen M, Dekker W, Blok P, Ferwerda J, Tytgat G . Intestinal metaplasia and Helicobacter pylori: an endoscopic bioptic study of the gastric antrum. Gut. 1992; 33(1):16-20. PMC: 1373858. DOI: 10.1136/gut.33.1.16. View

20.

Kainulainen L, Nikoskelainen J, Ruuskanen O . Diagnostic findings in 95 Finnish patients with common variable immunodeficiency. J Clin Immunol. 2001; 21(2):145-9. DOI: 10.1023/a:1011012023616. View