Intra-aneurysmal Hemodynamics During the Growth of an Unruptured Aneurysm: in Vitro Study Using Longitudinal CT Angiogram Database

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 2007 Apr 10

PMID 17416810

Citations 19

Authors

S Tateshima

K Tanishita

H Omura

J P Villablanca

F Vinuela

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: The role of blood-flow biomechanics on the size, morphology, and growth of cerebral aneurysms is poorly known. The purpose of this study was to evaluate intra-aneurysmal hemodynamics before and after aneurysm growth.

Materials And Methods: A flow-simulation study was performed in a middle cerebral artery (MCA) aneurysm with a bleb that grew after 1-year follow-up. Geometrically realistic in vitro models before and after aneurysm growth were constructed on the basis of CT angiograms. Blood-flow velocity, vorticity, and wall shear stress were obtained by using particle imaging velocimetry and laser Doppler velocimetry.

Results: No significant quantitative differences were noted among the overall flow structures before and after aneurysm growth, with the exception of less vorticity in the bleb after aneurysm growth. A circulating flow pattern was seen within the aneurysm domes. A blood-flow separation was observed at the margins of the bleb. No impingement of inward flow into the enlarging bleb was noted. Before the aneurysm growth, the wall shear stress was high at the aneurysm neck and also at the margin of the bleb. The value of wall shear stress decreased in the deeper part of the bleb. This value decreased even more after the aneurysm growth.

Conclusions: Intra-aneurysmal hemodynamic structures before and after the growth of an MCA aneurysm were compared. Further investigation with a similar approach is mandatory to obtain a firm conclusion.

Citing Articles

Morphological and Hemodynamic Changes during Cerebral Aneurysm Growth.

Nordahl E, Uthamaraj S, Dennis K, Sejkorova A, Hejcl A, Hron J Brain Sci. 2021; 11(4).

PMID: 33921861 PMC: 8073033. DOI: 10.3390/brainsci11040520.

Associations between morphology and hemodynamics of intracranial aneurysms based on 4D flow and black-blood magnetic resonance imaging.

Zhang M, Peng F, Li Y, He L, Liu A, Li R Quant Imaging Med Surg. 2021; 11(2):597-607.

PMID: 33532260 PMC: 7779904. DOI: 10.21037/qims-20-440.

Identification of Hostile Hemodynamics and Geometries of Cerebral Aneurysms: A Case-Control Study.

Chung B, Mut F, Putman C, Hamzei-Sichani F, Brinjikji W, Kallmes D AJNR Am J Neuroradiol. 2018; 39(10):1860-1866.

PMID: 30166431 PMC: 6177283. DOI: 10.3174/ajnr.A5764.

Intercorrelations of morphology with hemodynamics in intracranial aneurysms in computational fluid dynamics.

Qiu T, Jin G, Bao W, Lu H Neurosciences (Riyadh). 2017; 22(3):205-212.

PMID: 28678215 PMC: 5946365. DOI: 10.17712/nsj.2017.3.20160452.

Wall shear stress in intracranial aneurysms and adjacent arteries.

Wang F, Xu B, Sun Z, Wu C, Zhang X Neural Regen Res. 2014; 8(11):1007-15.

PMID: 25206394 PMC: 4145888. DOI: 10.3969/j.issn.1673-5374.2013.11.006.

References

Ujiie H, Tachibana H, Hiramatsu O, Hazel A, Matsumoto T, Ogasawara Y . Effects of size and shape (aspect ratio) on the hemodynamics of saccular aneurysms: a possible index for surgical treatment of intracranial aneurysms. Neurosurgery. 1999; 45(1):119-29; discussion 129-30. DOI: 10.1097/00006123-199907000-00028. View

Kamiya A, Ando J, Shibata M, Masuda H . Roles of fluid shear stress in physiological regulation of vascular structure and function. Biorheology. 1988; 25(1-2):271-8. DOI: 10.3233/bir-1988-251-236. View

Jou L, Quick C, Young W, Lawton M, Higashida R, Martin A . Computational approach to quantifying hemodynamic forces in giant cerebral aneurysms. AJNR Am J Neuroradiol. 2003; 24(9):1804-10. PMC: 7976294. View

Hassan T, Timofeev E, Saito T, Shimizu H, Ezura M, Matsumoto Y . A proposed parent vessel geometry-based categorization of saccular intracranial aneurysms: computational flow dynamics analysis of the risk factors for lesion rupture. J Neurosurg. 2005; 103(4):662-80. DOI: 10.3171/jns.2005.103.4.0662. View

Fukuda S, Hashimoto N, Naritomi H, Nagata I, Nozaki K, Kondo S . Prevention of rat cerebral aneurysm formation by inhibition of nitric oxide synthase. Circulation. 2000; 101(21):2532-8. DOI: 10.1161/01.cir.101.21.2532. View

Imbesi S, Knox K, Kerber C . Aneurysm flow dynamics: alterations of slipstream flow for neuroendovascular treatment with liquid embolic agents. AJNR Am J Neuroradiol. 2003; 24(10):2044-9. PMC: 8148925. View

Mantha A, Karmonik C, Benndorf G, Strother C, Metcalfe R . Hemodynamics in a cerebral artery before and after the formation of an aneurysm. AJNR Am J Neuroradiol. 2006; 27(5):1113-8. PMC: 7975719. View

Sho E, Sho M, Singh T, Nanjo H, Komatsu M, Xu C . Arterial enlargement in response to high flow requires early expression of matrix metalloproteinases to degrade extracellular matrix. Exp Mol Pathol. 2002; 73(2):142-53. DOI: 10.1006/exmp.2002.2457. View

Satoh T, Onoda K, Tsuchimoto S . Visualization of intraaneurysmal flow patterns with transluminal flow images of 3D MR angiograms in conjunction with aneurysmal configurations. AJNR Am J Neuroradiol. 2003; 24(7):1436-45. PMC: 7973683. View

10.

Shojima M, Oshima M, Takagi K, Torii R, Hayakawa M, Katada K . Magnitude and role of wall shear stress on cerebral aneurysm: computational fluid dynamic study of 20 middle cerebral artery aneurysms. Stroke. 2004; 35(11):2500-5. DOI: 10.1161/01.STR.0000144648.89172.0f. View

11.

Cebral J, Castro M, Burgess J, Pergolizzi R, Sheridan M, Putman C . Characterization of cerebral aneurysms for assessing risk of rupture by using patient-specific computational hemodynamics models. AJNR Am J Neuroradiol. 2005; 26(10):2550-9. PMC: 7976176. View

12.

Morimoto M, Miyamoto S, Mizoguchi A, Kume N, Kita T, Hashimoto N . Mouse model of cerebral aneurysm: experimental induction by renal hypertension and local hemodynamic changes. Stroke. 2002; 33(7):1911-5. DOI: 10.1161/01.str.0000021000.19637.3d. View

13.

Luscher T, Tanner F . Endothelial regulation of vascular tone and growth. Am J Hypertens. 1993; 6(7 Pt 2):283S-293S. DOI: 10.1093/ajh/6.7.283s. View

14.

Isoda H, Hirano M, Takeda H, Kosugi T, Alley M, Markl M . Visualization of hemodynamics in a silicon aneurysm model using time-resolved, 3D, phase-contrast MRI. AJNR Am J Neuroradiol. 2006; 27(5):1119-22. PMC: 7975756. View

15.

Kataoka K, Taneda M, Asai T, Kinoshita A, Ito M, Kuroda R . Structural fragility and inflammatory response of ruptured cerebral aneurysms. A comparative study between ruptured and unruptured cerebral aneurysms. Stroke. 1999; 30(7):1396-401. DOI: 10.1161/01.str.30.7.1396. View

16.

Schoning M, Buchholz R, Walter J . Comparative study of transcranial color duplex sonography and transcranial Doppler sonography in adults. J Neurosurg. 1993; 78(5):776-84. DOI: 10.3171/jns.1993.78.5.0776. View

17.

Wiebers D, Torner J, Meissner I . Impact of unruptured intracranial aneurysms on public health in the United States. Stroke. 1992; 23(10):1416-9. DOI: 10.1161/01.str.23.10.1416. View

18.

Tateshima S, Murayama Y, Villablanca J, Morino T, Takahashi H, Yamauchi T . Intraaneurysmal flow dynamics study featuring an acrylic aneurysm model manufactured using a computerized tomography angiogram as a mold. J Neurosurg. 2002; 95(6):1020-7. DOI: 10.3171/jns.2001.95.6.1020. View

19.

Villablanca J, Hooshi P, Martin N, Jahan R, Duckwiler G, Lim S . Three-dimensional helical computerized tomography angiography in the diagnosis, characterization, and management of middle cerebral artery aneurysms: comparison with conventional angiography and intraoperative findings. J Neurosurg. 2003; 97(6):1322-32. DOI: 10.3171/jns.2002.97.6.1322. View

20.

Steinman D, Milner J, Norley C, Lownie S, Holdsworth D . Image-based computational simulation of flow dynamics in a giant intracranial aneurysm. AJNR Am J Neuroradiol. 2003; 24(4):559-66. PMC: 8148673. View