Effect of Aldehydes Derived from Oxidative Deamination and Oxidative Stress on Beta-amyloid Aggregation; Pathological Implications to Alzheimer's Disease

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2007 Apr 3

PMID 17401529

Citations 17

Authors

K Chen

M Kazachkov

P H Yu

Affiliations

Soon will be listed here.

Abstract

Formaldehyde and methylglyoxal are generated via deamination from methylamine and aminoacetone respectively catalyzed by semicarbazide-sensitive amine oxidase (SSAO). Malondialdehyde (MDA) and 4-hydroxynonenal (HNE) are end products of lipid peroxidation due to oxidative stress. These aldehydes are capable of inducing protein cross-linkage. Elevated levels of aldehydes were found in Alzheimer's disease (AD). These reactive metabolites may potentially play important roles in beta-amyloid (Abeta) aggregation related to the pathology of AD. In the present study thioflavin-T (ThT) fluorometry, an immuno-dot-blot assay and atomic force microscopy (AFM) were employed to reveal the effect of aldehydes on Abeta aggregation in vitro. The target on Abeta for interaction with formaldehyde was identified. The results support the involvement of endogenous aldehydes in amyloid deposition related to AD.

Citing Articles

SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer's Disease.

Unzeta M, Hernandez-Guillamon M, Sun P, Sole M Int J Mol Sci. 2021; 22(7).

PMID: 33805974 PMC: 8036996. DOI: 10.3390/ijms22073365.

Catechol-Type Flavonoids from the Branches of f. Exert Antioxidant Activity and an Inhibitory Effect on Amyloid-β Aggregation.

Kim Y, Sohn E, Kim J, Na M, Jeong S Molecules. 2020; 25(21).

PMID: 33114256 PMC: 7660689. DOI: 10.3390/molecules25214917.

Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension.

Prinsen J, Kannankeril P, Sidorova T, Yermalitskaya L, Boutaud O, Zagol-Ikapitte I JACC Basic Transl Sci. 2020; 5(6):602-615.

PMID: 32613146 PMC: 7315188. DOI: 10.1016/j.jacbts.2020.04.004.

Safety and Efficacy of 630-nm Red Light on Cognitive Function in Older Adults With Mild to Moderate Alzheimer's Disease: Protocol for a Randomized Controlled Study.

Huang N, Yao D, Jiang W, Wei C, Li M, Li W Front Aging Neurosci. 2020; 12:143.

PMID: 32528273 PMC: 7253693. DOI: 10.3389/fnagi.2020.00143.

Formaldehyde, Epigenetics, and Alzheimer's Disease.

Wang F, Chen D, Wu P, Klein C, Jin C Chem Res Toxicol. 2019; 32(5):820-830.

PMID: 30964647 PMC: 6878761. DOI: 10.1021/acs.chemrestox.9b00090.

References

Sayre L, Zelasko D, Harris P, Perry G, Salomon R, Smith M . 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem. 1997; 68(5):2092-7. DOI: 10.1046/j.1471-4159.1997.68052092.x. View

Kawai M, Kalaria R, Cras P, Siedlak S, Velasco M, Shelton E . Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease. Brain Res. 1993; 623(1):142-6. DOI: 10.1016/0006-8993(93)90021-e. View

Dei R, Takeda A, Niwa H, Li M, Nakagomi Y, Watanabe M . Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease. Acta Neuropathol. 2002; 104(2):113-22. DOI: 10.1007/s00401-002-0523-y. View

Stanyer L, Betteridge D, Smith C . Exaggerated polymerisation of beta-amyloid 40 stimulated by plasma lipoproteins results in fibrillar Abeta preparations that are ineffective in promoting ADP-induced platelet aggregation. Biochim Biophys Acta. 2004; 1674(3):305-11. DOI: 10.1016/j.bbagen.2004.07.005. View

Messier C . Diabetes, Alzheimer's disease and apolipoprotein genotype. Exp Gerontol. 2003; 38(9):941-6. DOI: 10.1016/s0531-5565(03)00153-0. View

Thornalley P . Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic options. Int Rev Neurobiol. 2002; 50:37-57. DOI: 10.1016/s0074-7742(02)50072-6. View

Gubisne-Haberle D, Hill W, Kazachkov M, Richardson J, Yu P . Protein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine. J Pharmacol Exp Ther. 2004; 310(3):1125-32. DOI: 10.1124/jpet.104.068601. View

Roher A, Lowenson J, Clarke S, Woods A, Cotter R, Gowing E . beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc Natl Acad Sci U S A. 1993; 90(22):10836-40. PMC: 47873. DOI: 10.1073/pnas.90.22.10836. View

Kayed R, Head E, Thompson J, McIntire T, Milton S, Cotman C . Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003; 300(5618):486-9. DOI: 10.1126/science.1079469. View

10.

Luchsinger J, Tang M, Stern Y, Shea S, Mayeux R . Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort. Am J Epidemiol. 2001; 154(7):635-41. DOI: 10.1093/aje/154.7.635. View

11.

Subbarao K, Richardson J, Ang L . Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J Neurochem. 1990; 55(1):342-5. DOI: 10.1111/j.1471-4159.1990.tb08858.x. View

12.

Yu P, Wright S, Fan E, Lun Z, Gubisne-Harberle D . Physiological and pathological implications of semicarbazide-sensitive amine oxidase. Biochim Biophys Acta. 2003; 1647(1-2):193-9. DOI: 10.1016/s1570-9639(03)00101-8. View

13.

Boomsma F, de Kam P, Tjeerdsma G, van den Meiracker A, van Veldhuisen D . Plasma semicarbazide-sensitive amine oxidase (SSAO) is an independent prognostic marker for mortality in chronic heart failure. Eur Heart J. 2000; 21(22):1859-63. DOI: 10.1053/euhj.2000.2176. View

14.

McGrath L, McGleenon B, Brennan S, McColl D, McIlroy S, Passmore A . Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde. QJM. 2001; 94(9):485-90. DOI: 10.1093/qjmed/94.9.485. View

15.

Kazachkov M, Yu P . A novel HPLC procedure for detection and quantification of aminoacetone, a precursor of methylglyoxal, in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2005; 824(1-2):116-22. DOI: 10.1016/j.jchromb.2005.07.006. View

16.

Selkoe D . Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001; 81(2):741-66. DOI: 10.1152/physrev.2001.81.2.741. View

17.

Hernandez M, Esteban M, Szabo P, Boada M, Unzeta M . Human plasma semicarbazide sensitive amine oxidase (SSAO), beta-amyloid protein and aging. Neurosci Lett. 2005; 384(1-2):183-7. DOI: 10.1016/j.neulet.2005.04.074. View

18.

Yu P, Deng Y . Endogenous formaldehyde as a potential factor of vulnerability of atherosclerosis: involvement of semicarbazide-sensitive amine oxidase-mediated methylamine turnover. Atherosclerosis. 1998; 140(2):357-63. DOI: 10.1016/s0021-9150(98)00142-7. View

19.

Jellinger K . Alzheimer disease and cerebrovascular pathology: an update. J Neural Transm (Vienna). 2002; 109(5-6):813-36. DOI: 10.1007/s007020200068. View

20.

Ma J, Yee A, BREWER Jr H, Das S, Potter H . Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature. 1994; 372(6501):92-4. DOI: 10.1038/372092a0. View