Dual Gradient-echo MRI of Post-contraction Changes in Skeletal Muscle Blood Volume and Oxygenation

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2007 Mar 29

PMID 17390346

Citations 27

Authors

Bruce M Damon

Jennifer L Hornberger

Megan C Wadington

Drew A Lansdown

Jane A Kent-Braun

Affiliations

Soon will be listed here.

Abstract

Analysis of post-contraction MRI signal intensity (SI) transients may allow noninvasive studies of microvascular reactivity and blood oxygenation recovery. The purpose of this study was to determine the physiological basis for post-contraction changes in short-echo (6 ms) and long-echo (46 ms) gradient-echo (GRE) MRI signals (S(6) and S(46), respectively). Six healthy subjects were studied with the use of dual GRE MRI and near-infrared spectroscopy (NIRS). S(6), S(46), total hemoglobin concentration ([THb]), and oxyhemoglobin saturation (%HbO(2)) were measured before, during, and after 2 and 8 s dorsiflexion maximal voluntary contractions, and 5 min of proximal arterial occlusion. The changes in S(6) and [THb] after the 2-s contractions were similar to those following 8-s contractions, but changes in %HbO(2) and S(46) were greater following 8-s contractions than after the 2-s contractions. [THb] and S(6) did not change during and following 5 min of arterial occlusion, but %HbO(2) and S(46) were both significantly depressed at similar occlusion durations. Also, distance measures indicated similarity between S(6) and [THb] and between S(46) and %HbO(2). We conclude that following brief human skeletal muscle contractions, changes in S(6) primarily reflect changes in blood volume and changes in S(46) primarily reflect changes in blood oxygenation.

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References

Toussaint J, Kwong K, Mkparu F, Weisskoff R, Laraia P, KANTOR H . Perfusion changes in human skeletal muscle during reactive hyperemia measured by echo-planar imaging. Magn Reson Med. 1996; 35(1):62-9. DOI: 10.1002/mrm.1910350109. View

Nemeth P, LOWRY O . Myoglobin levels in individual human skeletal muscle fibers of different types. J Histochem Cytochem. 1984; 32(11):1211-6. DOI: 10.1177/32.11.6491255. View

Richardson R, Duteil S, Wary C, Wray D, Hoff J, Carlier P . Human skeletal muscle intracellular oxygenation: the impact of ambient oxygen availability. J Physiol. 2006; 571(Pt 2):415-24. PMC: 1796788. DOI: 10.1113/jphysiol.2005.102327. View

FLEAR C, Carpenter R, FLORENCE I . VARIABILITY IN THE WATER, SODIUM, POTASSIUM, AND CHLORIDE CONTENT OF HUMAN SKELETAL MUSCLE. J Clin Pathol. 1965; 18:74-81. PMC: 472836. DOI: 10.1136/jcp.18.1.74. View

Maguire M, Weaver T, Damon B . Delayed blood reoxygenation following maximum voluntary contraction. Med Sci Sports Exerc. 2007; 39(2):257-67. DOI: 10.1249/01.mss.0000246990.25858.47. View

Stables L, Kennan R, Gore J . Asymmetric spin-echo imaging of magnetically inhomogeneous systems: theory, experiment, and numerical studies. Magn Reson Med. 1998; 40(3):432-42. DOI: 10.1002/mrm.1910400314. View

Damon B, Gregory C, Hall K, Stark H, Gulani V, Dawson M . Intracellular acidification and volume increases explain R(2) decreases in exercising muscle. Magn Reson Med. 2002; 47(1):14-23. DOI: 10.1002/mrm.10043. View

Kalliokoski K, Kemppainen J, Larmola K, Takala T, Peltoniemi P, Oksanen A . Muscle blood flow and flow heterogeneity during exercise studied with positron emission tomography in humans. Eur J Appl Physiol. 2001; 83(4 -5):395-401. DOI: 10.1007/s004210000267. View

Thulborn K, Waterton J, Matthews P, Radda G . Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta. 1982; 714(2):265-70. DOI: 10.1016/0304-4165(82)90333-6. View

10.

Kalliokoski K, Kuusela T, Nuutila P, Tolvanen T, Oikonen V, Teras M . Perfusion heterogeneity in human skeletal muscle: fractal analysis of PET data. Eur J Nucl Med. 2001; 28(4):450-6. DOI: 10.1007/s002590000458. View

11.

Kalliokoski K, Laaksonen M, Takala T, Knuuti J, Nuutila P . Muscle oxygen extraction and perfusion heterogeneity during continuous and intermittent static exercise. J Appl Physiol (1985). 2002; 94(3):953-8. DOI: 10.1152/japplphysiol.00731.2002. View

12.

van Beekvelt M, Borghuis M, van Engelen B, Wevers R, Colier W . Adipose tissue thickness affects in vivo quantitative near-IR spectroscopy in human skeletal muscle. Clin Sci (Lond). 2001; 101(1):21-8. DOI: 10.1042/cs20000247. View

13.

Hickson R . Skeletal muscle cytochrome c and myoglobin, endurance, and frequency of training. J Appl Physiol Respir Environ Exerc Physiol. 1981; 51(3):746-9. DOI: 10.1152/jappl.1981.51.3.746. View

14.

Towse T, Slade J, Meyer R . Effect of physical activity on MRI-measured blood oxygen level-dependent transients in skeletal muscle after brief contractions. J Appl Physiol (1985). 2005; 99(2):715-22. PMC: 8495996. DOI: 10.1152/japplphysiol.00272.2005. View

15.

Lanza I, Befroy D, Kent-Braun J . Age-related changes in ATP-producing pathways in human skeletal muscle in vivo. J Appl Physiol (1985). 2005; 99(5):1736-44. DOI: 10.1152/japplphysiol.00566.2005. View

16.

Masuda K, Choi J, Shimojo H, Katsuta S . Maintenance of myoglobin concentration in human skeletal muscle after heavy resistance training. Eur J Appl Physiol Occup Physiol. 1999; 79(4):347-52. DOI: 10.1007/s004210050519. View

17.

Lebon V, Brillault-Salvat C, Bloch G, Leroy-Willig A, Carlier P . Evidence of muscle BOLD effect revealed by simultaneous interleaved gradient-echo NMRI and myoglobin NMRS during leg ischemia. Magn Reson Med. 1998; 40(4):551-8. DOI: 10.1002/mrm.1910400408. View

18.

Gray S, Staub N . Resistance to blood flow in leg muscles of dog during tetanic isometric contraction. Am J Physiol. 1967; 213(3):677-82. DOI: 10.1152/ajplegacy.1967.213.3.677. View

19.

Prior B, Ploutz-Snyder L, Cooper T, Meyer R . Fiber type and metabolic dependence of T2 increases in stimulated rat muscles. J Appl Physiol (1985). 2001; 90(2):615-23. DOI: 10.1152/jappl.2001.90.2.615. View

20.

Wigmore D, Damon B, Pober D, Kent-Braun J . MRI measures of perfusion-related changes in human skeletal muscle during progressive contractions. J Appl Physiol (1985). 2004; 97(6):2385-94. DOI: 10.1152/japplphysiol.01390.2003. View