Acquisition and Expression of a Socially Mediated Separation Response

Separation and reunion responses have been used to investigate social relationships in many species, including humans. When isolated from their mothers and siblings, infant rats vocalize in the ultrasonic range. An isolated pup reduces its rate of vocalization when placed in contact with familiar stimuli, particularly social ones such as its dam or littermates. The isolated pup's vocalization is greatly increased if the pup has been in contact with its mother immediately before isolation, a phenomenon called maternal potentiation. Early experience can play a role in the acquisition of potentiation. If rat pups are reared by both dam and sire, or even reared by the dam in the presence of the sire's odor, the pups show potentiation to the sire instead of the fear-related behavioral inhibition. Littermates, home cage shavings, and other familiar stimuli from the rearing environment do not elicit increased vocalizations during a subsequent isolation. The neurobiological mechanisms by which the sire becomes capable of potentiating vocalization are unknown, but are hypothesized to depend on the processes underlying development of an odor preference. Expression of potentiation is hypothesized to be related to reward processes in part because dopamine activity plays a regulatory role. Activation of dopamine type 2 receptors in the nucleus accumbens blocks maternal potentiation without altering vocalization rate in an initial isolation. The modulation of isolation-induced vocalization by social interactions provides a paradigm for investigating the neurobehavioral mechanisms underlying acquisition and expression of early life social bonds.