Metaplasia and Transdifferentiation: from Pure Biology to the Clinic

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2007 Mar 23

PMID 17377526

Citations 106

Authors

Jonathan M W Slack

Affiliations

Soon will be listed here.

Abstract

Transformations from one tissue type to another make up a well established set of phenomena that can be explained by the principles of developmental biology. Although these phenomena might be rare in nature, we can now imagine the possibility of deliberately reprogramming cells from one tissue type to another by manipulating the expression of transcription factors. This approach could generate new therapies for many human diseases.

Citing Articles

Transdifferentiation of plasmatocytes to crystal cells in the lymph gland of Drosophila melanogaster.

Marcetteau J, Duarte P, Leitao A, Sucena E EMBO Rep. 2025; .

PMID: 40075235 DOI: 10.1038/s44319-025-00366-z.

Perspective: Pathological transdifferentiation-a novel therapeutic target for cardiovascular diseases and chronic inflammation.

Yang W, Ben Issa M, Saaoud F, Xu K, Shao Y, Lu Y Front Cardiovasc Med. 2024; 11:1500775.

PMID: 39660114 PMC: 11628510. DOI: 10.3389/fcvm.2024.1500775.

A statistical approach for systematic identification of transition cells from scRNA-seq data.

Wang Y, Dede M, Mohanty V, Dou J, Li Z, Chen K Cell Rep Methods. 2024; 4(12):100913.

PMID: 39644902 PMC: 11704623. DOI: 10.1016/j.crmeth.2024.100913.

Data-driven structural analysis of small cell lung cancer transcription factor network suggests potential subtype regulators and transition pathways.

Ozen M, Lopez C NPJ Syst Biol Appl. 2023; 9(1):55.

PMID: 37907529 PMC: 10618210. DOI: 10.1038/s41540-023-00316-2.

The effects of statins on the function and differentiation of blood cells.

Chamani S, Kooshkaki O, Moossavi M, Rastegar M, Saffar Soflaei S, McCloskey A Arch Med Sci. 2023; 19(5):1314-1326.

PMID: 37732056 PMC: 10507790. DOI: 10.5114/aoms/158546.