Cardiac GPCRs: GPCR Signaling in Healthy and Failing Hearts

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2007 Mar 23

PMID 17376402

Citations 89

Authors

Natasha C Salazar

Juhsien Chen

Howard A Rockman

Affiliations

Soon will be listed here.

Abstract

G protein-coupled receptors (GPCRs) are widely implicated in human heart disease, making them an important target for cardiac drug therapy. The most commonly studied and clinically targeted cardiac GPCRs include the adrenergic, angiotensin, endothelin, and adenosine receptors. Treatment options focusing on the complex and integrated signaling pathways of these GPCRs are critical for the understanding and amelioration of heart disease. The focus of this review is to highlight the most commonly studied and clinically targeted cardiac GPCRs, placing emphasis on their common signaling components implicated in cardiac disease.

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