Proopiomelanocortin Expression in the Skin During Induced Hair Growth in Mice

Overview

Journal Experientia

Specialty Science

Date 1992 Jan 15

PMID 1737578

Citations 24

Authors

A Slominski

R Paus

J Mazurkiewicz

Affiliations

Soon will be listed here.

Abstract

We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti beta-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, beta-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.

Citing Articles

Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides.

Slominski A, Slominski R, Raman C, Chen J, Athar M, Elmets C Am J Physiol Cell Physiol. 2022; 323(6):C1757-C1776.

PMID: 36317800 PMC: 9744652. DOI: 10.1152/ajpcell.00147.2022.

The significance of CYP11A1 expression in skin physiology and pathology.

Slominski R, Raman C, Elmets C, Jetten A, Slominski A, Tuckey R Mol Cell Endocrinol. 2021; 530:111238.

PMID: 33716049 PMC: 8205265. DOI: 10.1016/j.mce.2021.111238.

Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders.

Slominski R, Tuckey R, Manna P, Jetten A, Postlethwaite A, Raman C Genes Immun. 2020; 21(3):150-168.

PMID: 32203088 PMC: 7276297. DOI: 10.1038/s41435-020-0096-6.

Neuroendocrine Aspects of Skin Aging.

Bocheva G, Slominski R, Slominski A Int J Mol Sci. 2019; 20(11).

PMID: 31181682 PMC: 6600459. DOI: 10.3390/ijms20112798.

Immune Privilege Collapse and Alopecia Development: Is Stress a Factor.

Azzawi S, Penzi L, Senna M Skin Appendage Disord. 2018; 4(4):236-244.

PMID: 30410890 PMC: 6219219. DOI: 10.1159/000485080.

References

Thody A, Shuster S . Control and function of sebaceous glands. Physiol Rev. 1989; 69(2):383-416. DOI: 10.1152/physrev.1989.69.2.383. View

Ferrando T, Rainero I, De Gennaro T, Oggero R, Mostert M, Dattola P . Beta-endorphin-like and alpha-MSH-like immunoreactivities in human milk. Life Sci. 1990; 47(7):633-5. DOI: 10.1016/0024-3205(90)90575-c. View

Smith A, Funder J . Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocr Rev. 1988; 9(1):159-79. DOI: 10.1210/edrv-9-1-159. View

Rheins L, Cotleur A, Kleier R, Hoppenjans W, Saunder D, Nordlund J . Alpha-melanocyte stimulating hormone modulates contact hypersensitivity responsiveness in C57/BL6 mice. J Invest Dermatol. 1989; 93(4):511-7. DOI: 10.1111/1523-1747.ep12284064. View

Uhler M, Herbert E, DEustachio P, Ruddle F . The mouse genome contains two nonallelic pro-opiomelanocortin genes. J Biol Chem. 1983; 258(15):9444-53. View

Paus R, Stenn K, Link R . Telogen skin contains an inhibitor of hair growth. Br J Dermatol. 1990; 122(6):777-84. DOI: 10.1111/j.1365-2133.1990.tb06266.x. View

Slominski A, Paus R, Costantino R . Differential expression and activity of melanogenesis-related proteins during induced hair growth in mice. J Invest Dermatol. 1991; 96(2):172-9. DOI: 10.1111/1523-1747.ep12460956. View

DeBold C, Menefee J, NICHOLSON W, ORTH D . Proopiomelanocortin gene is expressed in many normal human tissues and in tumors not associated with ectopic adrenocorticotropin syndrome. Mol Endocrinol. 1988; 2(9):862-70. DOI: 10.1210/mend-2-9-862. View

CHASE H . Growth of the hair. Physiol Rev. 1954; 34(1):113-26. DOI: 10.1152/physrev.1954.34.1.113. View

10.

Autelitano D, Lundblad J, Blum M, Roberts J . Hormonal regulation of POMC gene expression. Annu Rev Physiol. 1989; 51:715-26. DOI: 10.1146/annurev.ph.51.030189.003435. View

11.

Allen R, Orwoll E, KENDALL J, Herbert E, Paxton H . The distribution of forms of adrenocorticotropin and beta-endorphin in normal, tumorous, and autopsy human anterior pituiary tissue: virtual absence of 13K adrenocorticotropin. J Clin Endocrinol Metab. 1980; 51(2):376-80. DOI: 10.1210/jcem-51-2-376. View