Possible Role of Human Cytomegalovirus in Pouchitis After Proctocolectomy with Ileal Pouch-anal Anastomosis in Patients with Ulcerative Colitis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2007 Mar 22

PMID 17373744

Citations 9

Authors

Damian Casadesus

Tatsuo Tani

Toshifumi Wakai

Satoshi Maruyama

Tsuneo Iiai

Haruhiko Okamoto

Katsuyoshi Hatakeyama

Affiliations

Soon will be listed here.

Abstract

Aim: To detect the presence of human cytomegalovirus (HCMV) proteins and genes on the ileal pouch of patients with ulcerative colitis who have undergone proctocolectomy with ileal pouch-anal anastomosis (IPAA).

Methods: Immunohistochemistry, polymerase chain reaction (PCR) and PCR sequencing methods were utilized to test the presence of HCMV in pouch specimens taken from 34 patients in 86 endoscopies.

Results: HCMV genes and proteins were detected in samples from 12 (35.2%) patients. The rate of detection was significant in the endoscopies from patients diagnosed with pouchitis (5 of 12, 41.6%), according to the Japanese classification of pouchitis, in comparison to patients with normal pouch (7 of 62, 11.2%; P = 0.021). In all patients with pouchitis in which the HCMV was detected, it was the first episode of pouchitis. The virus was not detected in previous biopsies taken in normal endoscopies of these patients. During the follow-up, HCMV was detected in one patient with recurrent pouchitis and in 3 patients whose pouchitis episodes improved but whose positive endoscopic findings persisted.

Conclusion: HCMV can take part in the inflammatory process of the pouch in some patients with ulcerative colitis who have undergone proctocolectomy with IPAA.

Citing Articles

Common Inflammatory Disorders and Neoplasia of the Ileal Pouch: A Review of Histopathology.

Gonzalo D, Collinsworth A, Liu X Gastroenterology Res. 2016; 9(2-3):29-38.

PMID: 27785322 PMC: 5040541. DOI: 10.14740/gr706e.

Inflammatory pouch disease: The spectrum of pouchitis.

Zezos P, Saibil F World J Gastroenterol. 2015; 21(29):8739-52.

PMID: 26269664 PMC: 4528017. DOI: 10.3748/wjg.v21.i29.8739.

Protracted primary cytomegalovirus infection presenting as ileoanal pouchitis in a non-immunosuppressed patient: a case report.

Rupp C, Herpel E, Schnitzler P, Zawierucha A, Zwickel P, Klute L J Med Case Rep. 2014; 8:163.

PMID: 24885004 PMC: 4061925. DOI: 10.1186/1752-1947-8-163.

Cytomegalovirus infection of the ileoanal pouch: clinical characteristics and outcomes.

McCurdy J, Loftus Jr E, Tremaine W, Smyrk T, Bruining D, Pardi D Inflamm Bowel Dis. 2013; 19(11):2394-9.

PMID: 23974995 PMC: 4085480. DOI: 10.1097/MIB.0b013e3182a52553.

Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease.

Garrido E, Carrera E, Manzano R, Lopez-Sanroman A World J Gastroenterol. 2013; 19(1):17-25.

PMID: 23326158 PMC: 3545225. DOI: 10.3748/wjg.v19.i1.17.

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