Molecular Identification of a Novel G1 VP7 Gene Carried by a Human Rotavirus with a Super-short RNA Pattern

Overview

Journal Virus Genes

Specialties Microbiology
Molecular Biology

Date 2007 Mar 17

PMID 17364228

Citations 5

Authors

Kamruddin Ahmed

Toyoko Nakagomi

Osamu Nakagomi

Affiliations

Soon will be listed here.

Abstract

AU19 is a human rotavirus strain carrying a G1P2C[6] specificity and a super-short RNA pattern. Neutralization assay revealed an asymmetric cross neutralization between AU19 and Wa, a representative G1 rotavirus strain, and it is noteworthy that AU19 was neutralized poorly by anti-Wa hyper-immune serum. In the phylogenetic tree the VP7 gene of AU19 formed a lineage different from the established lineages of known human G1 rotaviruses. A signature code MFTKLLTAA was noted for AU19 lineage. These results provide evidences that the VP7 gene of AU19 represents a novel G1 lineage.

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