TORC1 is a Calcium- and CAMP-sensitive Coincidence Detector Involved in Hippocampal Long-term Synaptic Plasticity

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2007 Mar 16

PMID 17360587

Citations 88

Authors

Krisztian A Kovacs

Pascal Steullet

Myriam Steinmann

Kim Q Do

Pierre J Magistretti

Olivier Halfon

Jean-Rene Cardinaux

Affiliations

Soon will be listed here.

Abstract

A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term memory, requires gene transcription and protein synthesis. In this study, we report that a recently cloned coactivator of cAMP-response element-binding protein (CREB), called transducer of regulated CREB activity 1 (TORC1), contributes to this process by sensing the coincidence of calcium and cAMP signals in neurons and by converting it into a transcriptional response that leads to the synthesis of factors required for enhanced synaptic transmission. We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus.

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