Association of Poor Clinical Status and Heavy Exposure to Tobacco Smoke in Patients with Cystic Fibrosis Who Are Homozygous for the F508 Deletion

Overview

Journal J Pediatr

Specialty Pediatrics

Date 1992 Feb 1

PMID 1735823

Citations 27

Authors

P W Campbell 3rd

R A Parker

B T Roberts

M R Krishnamani

J A Phillips 3rd

Affiliations

Soon will be listed here.

Abstract

We examined the association between clinical status and exposure to tobacco smoke in 44 patients homozygous for the F508 cystic fibrosis mutation. Heavy exposure to tobacco smoke was significantly associated with lower Shwachman scores, poorer results of pulmonary function tests, and a fivefold increase in the number of pulmonary-related hospitalizations during the previous year.

Citing Articles

Lung function and secondhand smoke exposure among children with cystic fibrosis: A Bayesian meta-analysis.

Reifenberg J, Gecili E, Pestian T, Andrinopoulou E, Ryan P, Brokamp C J Cyst Fibros. 2023; 22(4):694-701.

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The Impact of Air Pollution on the Course of Cystic Fibrosis: A Review.

Blayac M, Coll P, Urbach V, Fanen P, Epaud R, Lanone S Front Physiol. 2022; 13:908230.

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Oates G, Baker E, Collaco J, Rowe S, Rutland S, Fowler C J Cyst Fibros. 2021; 20(4):618-624.

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Tensin 1 (TNS1) is a modifier gene for low body mass index (BMI) in homozygous [F508del]CFTR patients.

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