Artesunate--amodiaquine Combination Therapy for Falciparum Malaria in Young Gabonese Children

Overview

Journal Malar J

Publisher Biomed Central

Specialty Tropical Medicine

Date 2007 Mar 14

PMID 17352806

Citations 17

Authors

Sunny Oyakhirome

Marc Potschke

Norbert G Schwarz

Jenny Dornemann

Matthias Laengin

Carmen Ospina Salazar

Bertrand Lell

Jurgen F J Kun

Peter G Kremsner

Martin P Grobusch

Affiliations

Soon will be listed here.

Abstract

Background: Artesunate-amodiaquine combination for the treatment of childhood malaria is one of the artemisinin combination therapies (ACTs) recommended by National authorities in many African countries today. Effectiveness data on this combination in young children is scarce.

Methods: The effectiveness of three daily doses of artesunate plus amodiaquine combination given unsupervised (n = 32), compared with the efficacy when given under full supervision (n = 29) to children with falciparum malaria were assessed in an unrandomized study.

Results: 61 patients analysed revealed a PCR-corrected day-28 cure rate of 86 % (25 of 29 patients; CI 69-95 %) in the supervised group and 63 % (20 of 32 patients; CI 45-77 %) in the unsupervised group. The difference in outcome between both groups was statistically significant (p = 0.04). No severe adverse events were reported.

Conclusion: The effectiveness of this short course regimen in young children with falciparum malaria could be augmented by increased adherence and improved formulation.

Citing Articles

Slow clearance of histidine-rich protein-2 in Gabonese with uncomplicated malaria.

Lamsfus Calle C, Schaumburg F, Rieck T, Nkoma Mouima A, Martinez de Salazar P, Breil S Microbiol Spectr. 2024; 12(10):e0099424.

PMID: 39194289 PMC: 11449231. DOI: 10.1128/spectrum.00994-24.

Funding patterns for biomedical research and infectious diseases burden in Gabon.

Adegnika O, Josiane Honkpehedji Y, Mougeni Lotola F, Agnandji S, Adegnika A, Lell B BMC Public Health. 2021; 21(1):2155.

PMID: 34819025 PMC: 8611934. DOI: 10.1186/s12889-021-12201-w.

Differential Prevalences of Polymorphisms in Symptomatic and Asymptomatic Infections in Lastoursville: A Rural Area in East-Central Gabon.

Ontoua S, Kouna L, Oyegue-Liabagui S, Voumbo-Matoumona D, Moukodoum D, Imboumy-Limoukou R Infect Drug Resist. 2021; 14:2873-2882.

PMID: 34335033 PMC: 8318719. DOI: 10.2147/IDR.S304361.

Monitoring of efficacy, tolerability and safety of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon: an open-label clinical trial.

Adegbite B, Edoa J, Honkpehedji Y, Zinsou F, Dejon-Agobe J, Mbong-Ngwese M Malar J. 2019; 18(1):424.

PMID: 31842893 PMC: 6916217. DOI: 10.1186/s12936-019-3015-4.

Hematological and biochemical effects of sub-chronic artesunate exposure in rats.

Bigoniya P, Sahu T, Tiwari V Toxicol Rep. 2017; 2:280-288.

PMID: 28962361 PMC: 5598518. DOI: 10.1016/j.toxrep.2015.01.007.

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