Human Tumor-derived Vs Dendritic Cell-derived Exosomes Have Distinct Biologic Roles and Molecular Profiles

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2007 Mar 6

PMID 17337785

Citations 74

Authors

Eva Wieckowski

Theresa L Whiteside

Affiliations

Soon will be listed here.

Abstract

Microvesicles (MV) or exosomes are produced and secreted by tumor and normal cells. The molecular profile and functions of tumor-derived vs dendritic cell (DC)-derived MV are distinct. The former express death ligands and mediate apoptosis of activated T cells. The latter promote CD4+ T cell proliferation and may play a role in regulating T cell responses. Serving as intercellular communication networks, tumor-derived MV contribute to tumor escape, while DC-derived MV drive and regulate immune response.

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