Prospective, Randomized Trial of Metformin and Vitamins for the Reduction of Plasma Homocysteine in Insulin-resistant Polycystic Ovary Syndrome
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One hundred and two women with insulin-resistant polycystic ovary syndrome were randomized to treatment with a vitamin B preparation, metformin, or both, in conjunction with standard infertility treatment. Plasma homocysteine levels were significantly reduced by both B vitamins and metformin, but to a greater degree by B vitamins, and higher pregnancy rates were associated with vitamin B treatment.
Ulloque-Badaracco J, Al-Kassab-Cordova A, Hernandez-Bustamante E, Alarcon-Braga E, Cabrera-Guzman J, Horruitiner-Mendoza A Womens Health (Lond). 2024; 20:17455057241279039.
PMID: 39320480 PMC: 11437568. DOI: 10.1177/17455057241279039.
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