» Articles » PMID: 17321768

The Anorexic Effect of Alpha-melanocyte-stimulating Hormone is Mediated by Corticotrophin-releasing Factor in Chicks

Overview
Date 2007 Feb 27
PMID 17321768
Citations 11
Authors
Affiliations
Soon will be listed here.
Abstract

Alpha-melanocyte-stimulating hormone (alpha-MSH) is recognized as an anorexic peptide in the brain of vertebrates, but its mechanism of action has not been identified in birds. Therefore, we investigated whether the anorexic effect of alpha-MSH is mediated by corticotrophin-releasing factor (CRF) in the domestic chick. Firstly, we found that intracerebroventricular (i.c.v.) injection of alpha-MSH dose dependently increased plasma corticosterone (CORT) concentration. This effect was partly attenuated by co-injection of astressin, a CRF receptor antagonist, demonstrating that alpha-MSH stimulated CORT secretion by activating CRF neurons. The alpha-MSH-elicited CORT release was not attenuated by the injection of agouti-related protein, an endogenous melanocortin-4 (MC4) receptor antagonist, suggesting that alpha-MSH stimulated CRF neurons through MC4 receptor-independent pathways. Finally, we found that the anorexic effect of alpha-MSH was partly attenuated by astressin. The present results suggest that the anorexic effect of alpha-MSH in the chick brain is mediated in part by activation of CRF neurons.

Citing Articles

A bird's-eye overview of molecular mechanisms regulating feed intake in chickens-with mammalian comparisons.

Volyanskaya A, Akberdin I, Kulyashov M, Yevshin I, Romanov M, Shagimardanova E Anim Nutr. 2024; 17:61-74.

PMID: 38737579 PMC: 11087724. DOI: 10.1016/j.aninu.2024.01.008.


In ovo injection of cinnamon or clove alters the physiology and growth of broilers in a hot tropical environment.

Akosile O, Sogunle O, Majekodunmi B, Oke O Transl Anim Sci. 2023; 7(1):txad036.

PMID: 37091048 PMC: 10114525. DOI: 10.1093/tas/txad036.


Evaluation of access to different legume pastures on performance and welfare of broiler chickens during dry season under tropical environment.

Oke O, Akande J, Sodipo I, Ekunseitan D, Rahman S, Smith O Vet Med Sci. 2021; 7(4):1359-1368.

PMID: 33694325 PMC: 8294400. DOI: 10.1002/vms3.461.


Should I Lay or Should I Grow: Photoperiodic Versus Metabolic Cues in Chickens.

Hanlon C, Ramachandran R, Zuidhof M, Bedecarrats G Front Physiol. 2020; 11:707.

PMID: 32670092 PMC: 7332832. DOI: 10.3389/fphys.2020.00707.


Evaluation of physiological response and performance by supplementation of Curcuma longa in broiler feed under hot humid tropical climate.

Oke O Trop Anim Health Prod. 2018; 50(5):1071-1077.

PMID: 29404849 DOI: 10.1007/s11250-018-1532-8.