Acute Modulation of Cortical Oscillatory Activities During Short Trains of High-frequency Repetitive Transcranial Magnetic Stimulation of the Human Motor Cortex: a Combined EEG and TMS Study

Overview

Journal Hum Brain Mapp

Publisher Wiley

Specialty Neurology

Date 2007 Feb 24

PMID 17318833

Citations 45

Authors

Giorgio Fuggetta

Enea F Pavone

Antonio Fiaschi

Paolo Manganotti

Affiliations

Soon will be listed here.

Abstract

In this study, a combined repetitive transcranial magnetic stimulation/electroencephalography (rTMS/EEG) method was used to explore the acute changes of cortical oscillatory activity induced by intermittent short trains of high-frequency (5-Hz) rTMS delivered over the left primary motor cortex (M1). We evaluated the electrophysiological reaction to magnetic stimulation during and 2-4 s after 20 trains of 20-pulses rTMS, using event-related power (ERPow) that reflects the regional oscillatory activity of neural assemblies, and event-related coherence (ERCoh) that reflects the interregional functional connectivity of oscillatory neural activity. These event-related transformations were for the upper alpha (10-12 Hz) and beta (18-22 Hz) frequency ranges, respectively. For the alpha band, threshold rTMS and subthreshold rTMS induced an ERPow increase during the trains of stimulation mainly in frontal and central regions ipsilateral to stimulation. For the beta band, a similar synchronization of cortical oscillations for both rTMS intensities was seen. Moreover, subthreshold rTMS affected alpha-band activity more than threshold rTMS, inducing a specific ERCoh decrease over the posterior regions during the trains of stimulation. For beta band, the decrease in functional coupling was observed mainly during threshold rTMS. These findings provide a better understanding of the cortical effects of high-frequency rTMS, whereby the induction of oscillations reflects the capacity of electromagnetic pulses to alter regional and interregional synaptic transmissions of neural populations.

Citing Articles

Interactions of transcranial magnetic stimulation with brain oscillations: a narrative review.

Wang Q, Gong A, Feng Z, Bai Y, Ziemann U Front Syst Neurosci. 2024; 18:1489949.

PMID: 39698203 PMC: 11652484. DOI: 10.3389/fnsys.2024.1489949.

Fronto-central resting-state 15-29 Hz transient beta events change with therapeutic transcranial magnetic stimulation for posttraumatic stress disorder and major depressive disorder.

Morris A, Temereanca S, Zandvakili A, Thorpe R, Sliva D, Greenberg B Sci Rep. 2023; 13(1):6366.

PMID: 37076496 PMC: 10115889. DOI: 10.1038/s41598-023-32801-3.

Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation.

Jannati A, Oberman L, Rotenberg A, Pascual-Leone A Neuropsychopharmacology. 2022; 48(1):191-208.

PMID: 36198876 PMC: 9700722. DOI: 10.1038/s41386-022-01453-8.

Repetitive Transcranial Magnetic Stimulation of the Primary Motor Cortex beyond Motor Rehabilitation: A Review of the Current Evidence.

Tomeh A, Yusof Khan A, Inche Mat L, Basri H, Wan Sulaiman W Brain Sci. 2022; 12(6).

PMID: 35741646 PMC: 9221422. DOI: 10.3390/brainsci12060761.

The Effects of Intermittent Theta Burst Stimulation on Functional Brain Network Following Stroke: An Electroencephalography Study.

Ding Q, Zhang S, Chen S, Chen J, Li X, Chen J Front Neurosci. 2021; 15:755709.

PMID: 34744616 PMC: 8569250. DOI: 10.3389/fnins.2021.755709.

References

Modugno N, Nakamura Y, Mackinnon C, Filipovic S, Bestmann S, Berardelli A . Motor cortex excitability following short trains of repetitive magnetic stimuli. Exp Brain Res. 2001; 140(4):453-9. DOI: 10.1007/s002210100843. View

Pfurtscheller G, ARANIBAR A . Event-related cortical desynchronization detected by power measurements of scalp EEG. Electroencephalogr Clin Neurophysiol. 1977; 42(6):817-26. DOI: 10.1016/0013-4694(77)90235-8. View

Pfurtscheller G, Lopes da Silva F . Event-related EEG/MEG synchronization and desynchronization: basic principles. Clin Neurophysiol. 1999; 110(11):1842-57. DOI: 10.1016/s1388-2457(99)00141-8. View

Bestmann S, Baudewig J, Siebner H, Rothwell J, Frahm J . Functional MRI of the immediate impact of transcranial magnetic stimulation on cortical and subcortical motor circuits. Eur J Neurosci. 2004; 19(7):1950-62. DOI: 10.1111/j.1460-9568.2004.03277.x. View

Fuggetta G, Fiaschi A, Manganotti P . Modulation of cortical oscillatory activities induced by varying single-pulse transcranial magnetic stimulation intensity over the left primary motor area: a combined EEG and TMS study. Neuroimage. 2005; 27(4):896-908. DOI: 10.1016/j.neuroimage.2005.05.013. View

OLDFIELD R . The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971; 9(1):97-113. DOI: 10.1016/0028-3932(71)90067-4. View

Fein G, Raz J, Brown F, Merrin E . Common reference coherence data are confounded by power and phase effects. Electroencephalogr Clin Neurophysiol. 1988; 69(6):581-4. DOI: 10.1016/0013-4694(88)90171-x. View

Rappelsberger P, Petsche H . Probability mapping: power and coherence analyses of cognitive processes. Brain Topogr. 1988; 1(1):46-54. DOI: 10.1007/BF01129339. View

Pfurtscheller G, Neuper C, KRAUSZ G . Functional dissociation of lower and upper frequency mu rhythms in relation to voluntary limb movement. Clin Neurophysiol. 2000; 111(10):1873-9. DOI: 10.1016/s1388-2457(00)00428-4. View

10.

Peinemann A, Reimer B, Loer C, Quartarone A, Munchau A, Conrad B . Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5 Hz repetitive TMS to the primary motor cortex. Clin Neurophysiol. 2004; 115(7):1519-26. DOI: 10.1016/j.clinph.2004.02.005. View

11.

Kalcher J, Pfurtscheller G . Discrimination between phase-locked and non-phase-locked event-related EEG activity. Electroencephalogr Clin Neurophysiol. 1995; 94(5):381-4. DOI: 10.1016/0013-4694(95)00040-6. View

12.

Leocani L, Toro C, Manganotti P, Zhuang P, Hallett M . Event-related coherence and event-related desynchronization/synchronization in the 10 Hz and 20 Hz EEG during self-paced movements. Electroencephalogr Clin Neurophysiol. 1997; 104(3):199-206. DOI: 10.1016/s0168-5597(96)96051-7. View

13.

Strafella A, Paus T, Fraraccio M, Dagher A . Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex. Brain. 2003; 126(Pt 12):2609-15. DOI: 10.1093/brain/awg268. View

14.

Ziemann U . Intracortical inhibition and facilitation in the conventional paired TMS paradigm. Electroencephalogr Clin Neurophysiol Suppl. 1999; 51:127-36. View

15.

Rossini P, Barker A, Berardelli A, Caramia M, Caruso G, Cracco R . Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr Clin Neurophysiol. 1994; 91(2):79-92. DOI: 10.1016/0013-4694(94)90029-9. View

16.

Siebner H, Rothwell J . Transcranial magnetic stimulation: new insights into representational cortical plasticity. Exp Brain Res. 2002; 148(1):1-16. DOI: 10.1007/s00221-002-1234-2. View

17.

Bestmann S, Baudewig J, Siebner H, Rothwell J, Frahm J . Subthreshold high-frequency TMS of human primary motor cortex modulates interconnected frontal motor areas as detected by interleaved fMRI-TMS. Neuroimage. 2003; 20(3):1685-96. DOI: 10.1016/j.neuroimage.2003.07.028. View

18.

Quartarone A, Bagnato S, Rizzo V, Morgante F, Santangelo A, Battaglia F . Distinct changes in cortical and spinal excitability following high-frequency repetitive TMS to the human motor cortex. Exp Brain Res. 2004; 161(1):114-24. DOI: 10.1007/s00221-004-2052-5. View

19.

Tiihonen J, Kajola M, Hari R . Magnetic mu rhythm in man. Neuroscience. 1989; 32(3):793-800. DOI: 10.1016/0306-4522(89)90299-6. View

20.

Salmelin R, Hari R . Spatiotemporal characteristics of sensorimotor neuromagnetic rhythms related to thumb movement. Neuroscience. 1994; 60(2):537-50. DOI: 10.1016/0306-4522(94)90263-1. View