Functional and Anatomical Magnetic Resonance Imaging in Parkinson's Disease

Overview

Journal Mol Imaging Biol

Publisher Springer

Specialties Molecular Biology
Radiology

Date 2007 Feb 24

PMID 17318668

Citations 8

Authors

Alain Dagher

Atsuko Nagano-Saito

Affiliations

Soon will be listed here.

Abstract

For the past 15 years, measurements of cerebral blood flow as an indicator of neuronal activity have been used to gain a better understanding of the neural basis of motor and cognitive deficits in Parkinson's disease. The initial studies, using positron emission tomography, yielded results in keeping with the hypothesis that symptoms result from excessive cortical inhibition from cortico-striatal loops. However, subsequent studies with functional magnetic resonance imaging (fMRI) have shown that specific aspects of the paradigms used, such as the need to pay attention to one's movements, have a significant impact on activation patterns, which may complicate the interpretation of results. Functional neuroimaging has also been used to investigate the causes of cognitive impairment in Parkinson's disease. While some studies implicate dopamine loss in striatum, more recent investigations using anatomical MRI to measure cortical atrophy suggest that some cognitive deficits are attributable to direct cortical involvement by the disease.

Citing Articles

Functional reorganization of motor and limbic circuits after exercise training in a rat model of bilateral parkinsonism.

Wang Z, Myers K, Guo Y, Ocampo M, Pang R, Jakowec M PLoS One. 2013; 8(11):e80058.

PMID: 24278239 PMC: 3836982. DOI: 10.1371/journal.pone.0080058.

The centre of the brain: topographical model of motor, cognitive, affective, and somatosensory functions of the basal ganglia.

Arsalidou M, Duerden E, Taylor M Hum Brain Mapp. 2012; 34(11):3031-54.

PMID: 22711692 PMC: 6870003. DOI: 10.1002/hbm.22124.

Accounting for movement increases sensitivity in detecting brain activity in Parkinson's disease.

Holiga S, Moller H, Sieger T, Schroeter M, Jech R, Mueller K PLoS One. 2012; 7(5):e36271.

PMID: 22563486 PMC: 3341369. DOI: 10.1371/journal.pone.0036271.

Impairment of executive performance after transcranial magnetic modulation of the left dorsal frontal-striatal circuit.

van den Heuvel O, van Gorsel H, Veltman D, van der Werf Y Hum Brain Mapp. 2011; 34(2):347-55.

PMID: 22076808 PMC: 6870447. DOI: 10.1002/hbm.21443.

Imbalanced Dopaminergic Transmission Mediated by Serotonergic Neurons in L-DOPA-Induced Dyskinesia.

Navailles S, De Deurwaerdere P Parkinsons Dis. 2011; 2012:323686.

PMID: 22007343 PMC: 3191743. DOI: 10.1155/2012/323686.

References

Rascol O, Sabatini U, Chollet F, Celsis P, Montastruc J, Marc-Vergnes J . Supplementary and primary sensory motor area activity in Parkinson's disease. Regional cerebral blood flow changes during finger movements and effects of apomorphine. Arch Neurol. 1992; 49(2):144-8. DOI: 10.1001/archneur.1992.00530260044017. View

Hallett M . Physiology of basal ganglia disorders: an overview. Can J Neurol Sci. 1993; 20(3):177-83. DOI: 10.1017/s0317167100047909. View

Worsley K, Liao C, Aston J, Petre V, Duncan G, Morales F . A general statistical analysis for fMRI data. Neuroimage. 2002; 15(1):1-15. DOI: 10.1006/nimg.2001.0933. View

Samuel M, Ceballos-Baumann A, Boecker H, Brooks D . Motor imagery in normal subjects and Parkinson's disease patients: an H215O PET study. Neuroreport. 2001; 12(4):821-8. DOI: 10.1097/00001756-200103260-00040. View

Owen A, James M, Leigh P, Summers B, Marsden C, Quinn N . Fronto-striatal cognitive deficits at different stages of Parkinson's disease. Brain. 1992; 115 ( Pt 6):1727-51. DOI: 10.1093/brain/115.6.1727. View

Owen A . The functional organization of working memory processes within human lateral frontal cortex: the contribution of functional neuroimaging. Eur J Neurosci. 1997; 9(7):1329-39. DOI: 10.1111/j.1460-9568.1997.tb01487.x. View

Dagher A, Owen A, Boecker H, Brooks D . The role of the striatum and hippocampus in planning: a PET activation study in Parkinson's disease. Brain. 2001; 124(Pt 5):1020-32. DOI: 10.1093/brain/124.5.1020. View

Logothetis N, Pfeuffer J . On the nature of the BOLD fMRI contrast mechanism. Magn Reson Imaging. 2005; 22(10):1517-31. DOI: 10.1016/j.mri.2004.10.018. View

Albin R, Young A, Penney J . The functional anatomy of basal ganglia disorders. Trends Neurosci. 1989; 12(10):366-75. DOI: 10.1016/0166-2236(89)90074-x. View

10.

Grossman M, Cooke A, DEVITA C, Lee C, Alsop D, Detre J . Grammatical and resource components of sentence processing in Parkinson's disease: an fMRI study. Neurology. 2003; 60(5):775-81. DOI: 10.1212/01.wnl.0000044398.73241.13. View

11.

Bruck A, Portin R, Lindell A, LAIHINEN A, Bergman J, Haaparanta M . Positron emission tomography shows that impaired frontal lobe functioning in Parkinson's disease is related to dopaminergic hypofunction in the caudate nucleus. Neurosci Lett. 2001; 311(2):81-4. DOI: 10.1016/s0304-3940(01)02124-3. View

12.

Lewis S, Dove A, Robbins T, Barker R, Owen A . Cognitive impairments in early Parkinson's disease are accompanied by reductions in activity in frontostriatal neural circuitry. J Neurosci. 2003; 23(15):6351-6. PMC: 6740550. View

13.

Limousin P, Greene J, Pollak P, Rothwell J, Benabid A, Frackowiak R . Changes in cerebral activity pattern due to subthalamic nucleus or internal pallidum stimulation in Parkinson's disease. Ann Neurol. 1997; 42(3):283-91. DOI: 10.1002/ana.410420303. View

14.

Jenkins I, Fernandez W, Playford E, Lees A, Frackowiak R, Passingham R . Impaired activation of the supplementary motor area in Parkinson's disease is reversed when akinesia is treated with apomorphine. Ann Neurol. 1992; 32(6):749-57. DOI: 10.1002/ana.410320608. View

15.

Hilker R, Thomas A, Klein J, Weisenbach S, Kalbe E, Burghaus L . Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways. Neurology. 2005; 65(11):1716-22. DOI: 10.1212/01.wnl.0000191154.78131.f6. View

16.

Camicioli R, Moore M, Kinney A, Corbridge E, Glassberg K, Kaye J . Parkinson's disease is associated with hippocampal atrophy. Mov Disord. 2003; 18(7):784-90. DOI: 10.1002/mds.10444. View

17.

Logothetis N . The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal. Philos Trans R Soc Lond B Biol Sci. 2002; 357(1424):1003-37. PMC: 1693017. DOI: 10.1098/rstb.2002.1114. View

18.

Burton E, McKeith I, Burn D, Williams E, OBrien J . Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls. Brain. 2004; 127(Pt 4):791-800. DOI: 10.1093/brain/awh088. View

19.

Boecker H, Dagher A, Ceballos-Baumann A, Passingham R, Samuel M, Friston K . Role of the human rostral supplementary motor area and the basal ganglia in motor sequence control: investigations with H2 15O PET. J Neurophysiol. 1998; 79(2):1070-80. DOI: 10.1152/jn.1998.79.2.1070. View

20.

Playford E, Jenkins I, Passingham R, Nutt J, Frackowiak R, Brooks D . Impaired mesial frontal and putamen activation in Parkinson's disease: a positron emission tomography study. Ann Neurol. 1992; 32(2):151-61. DOI: 10.1002/ana.410320206. View