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Protection from Lethal Influenza Virus Challenge by Oral Type 1 Interferon

Overview
Journal Biochem Biophys Res Commun
Publisher Elsevier
Specialty Biochemistry
Date 2007 Feb 24
PMID 17316562
Citations 35
Authors
Manfred W Beilharz
Joseph M Cummins
Alayne L Bennett
Affiliations
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Abstract

The persistence of highly pathogenic avian influenza within wild bird populations has forged interest in control measures to limit a possible human pandemic. We therefore investigated the efficacy of low dose oral administration of IFN-alpha as a potential therapy against influenza infection in a murine model. We have identified an optimal low oral dose of IFN-alpha that when delivered daily as prophylactic therapy protects C57BL/6J mice from a lethal challenge with mouse adapted human influenza virus A/PR/8/34 (H1N1). These results provide strong support for the application of low dose type 1 IFN pretreatment to human influenza control.

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