Higher Thrombin Concentrations Are Required to Induce Platelet Apoptosis Than to Induce Platelet Activation

Primarily known as an inducer of blood coagulation and platelet activation, thrombin also triggers platelet apoptosis. This study demonstrated that the platelet activation response is much more sensitive than platelet apoptosis to thrombin treatment. Thrombin concentrations of 0.5-1 nmol/l activated almost all platelets, but only a small fraction underwent apoptosis, suggesting that at these relatively low thrombin concentrations, platelets may perform haemostasis but not be involved in programmed cell death. At high thrombin concentrations of 10-100 nmol/l, generated during blood coagulation, 30-40% of platelets became apoptotic, indicating that hypercoagulable states may be associated with increased numbers of apoptotic platelets.