Comparative Analysis of GDF 8 (myostatin) in Bos Indicus and Bos Taurus
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We report the myostatin gene sequence of Bos indicus cattle in comparison to Bos taurus. B. indicus genomic sequence was obtained by overlapping PCR amplification of genomic DNA. Exon splice sites were confirmed by mRNA sequencing. There were 5 exonic single nucleotide polymorphisms (SNP) only one of which was a non-synonymous mutation that resulted in a serine to asparagine (S214N) amino acid substitution. The B. indicus gene has two insertions of 16 and 12 bases in the first intron. In addition, SNPs in the 3' UTR and intronic regions are also reported.
Genetic variation in the first intron and exon of the gene in several Indonesian cattle populations.
Prihandini P, Primasari A, Aryogi A, Efendy J, Luthfi M, Pamungkas D Vet World. 2021; 14(5):1197-1201.
PMID: 34220121 PMC: 8243674. DOI: 10.14202/vetworld.2021.1197-1201.
Detection of myostatin gene MSTN in some goat breeds ().
Dowidar Y, El-Sayed M, Elrefy A, Shoura H J Genet Eng Biotechnol. 2019; 16(2):507-512.
PMID: 30733767 PMC: 6353733. DOI: 10.1016/j.jgeb.2018.04.002.
Age-related changes in craniofacial morphology in GDF-8 (myostatin)-deficient mice.
Vecchione L, Miller J, Byron C, Cooper G, Barbano T, Cray J Anat Rec (Hoboken). 2009; 293(1):32-41.
PMID: 19899116 PMC: 3113544. DOI: 10.1002/ar.21024.