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A Secondary Progressive Clinical Course is Uncommon in Neuromyelitis Optica

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Journal Neurology
Specialty Neurology
Date 2007 Feb 21
PMID 17310032
Citations 98
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Abstract

We compared the clinical course of 96 patients with neuromyelitis optica (NMO) to multiple sclerosis (MS) natural history data. Based on the distribution of follow-up data (median 6.1 year), we estimated that 21 NMO patients would convert to a secondary progressive course, but we observed only two conversions (p = 0.00002; relative risk = 0.08). The disparate natural histories of MS and NMO suggest dissociation between relapses and clinical progression in CNS demyelinating diseases.

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