Plurihormonality in Pituitary Adenomas Associated with Acromegaly

Overview

Journal Endocr Pathol

Specialties Endocrinology
Pathology

Date 2007 Feb 20

PMID 17308366

Citations 7

Authors

Fateme Salehi

Sandra Cohen

Luis V Syro

Humberto Uribe

Eva Horvath

Kalman Kovacs

Sylvia L Asa

Affiliations

Soon will be listed here.

Abstract

Bihormonal or plurihormonal pituitary tumors produce two or more hormones different in chemical composition, immunoreactivity, and clinical significance. Immunohistochemical and electron microscopic investigations and more recently molecular-genetic studies have provided conclusive evidence of the production of multiple hormones by pituitary adenomas. Most frequently, they produce GH, PRL, TSH, and/or alpha-subunit of the glycoprotein hormones. Other uncommon combinations may also be apparent. We report the case of a 40-yr-old acromegalic man with a pituitary macroadenoma. The pituitary tumor was removed by transsphenoidal surgery. Histological, immunohistochemical, electron microscopic, and immunoelectron microscopic examinations revealed that the tumor contains multiple hormones (GH, LH, and alpha subunit) and transcription factors. The application of different reagents yielded different patterns of positivity indicating that the validity of some common immunohistochemical reagents must be re-evaluated.

Citing Articles

Pathogenesis, clinical features, and treatment of plurihormonal pituitary adenoma.

Cai Y, Liu S, Zhao X, Ren L, Liu X, Gang X Front Neurosci. 2024; 17:1323883.

PMID: 38260014 PMC: 10800528. DOI: 10.3389/fnins.2023.1323883.

Acromegaly due to a Macroinvasive Plurihormonal Pituitary Adenoma and a Rectal Carcinoid Tumor.

Chin S, Hwang J, Rhee S, Chon S, Oh S, Lee M Endocrinol Metab (Seoul). 2015; 30(3):389-94.

PMID: 25559714 PMC: 4595365. DOI: 10.3803/EnM.2015.30.3.389.

Concurrent somatotroph and plurihormonal pituitary adenomas in a cat.

Sharman M, Fitzgerald L, Kiupel M J Feline Med Surg. 2013; 15(10):945-52.

PMID: 23553410 PMC: 11383157. DOI: 10.1177/1098612X13483461.

A rare corticotroph-secreting tumor with coexisting prolactin and growth hormone staining cells.

Kannan S, Staugaitis S, Weil R, Hatipoglu B Case Rep Endocrinol. 2013; 2012:529730.

PMID: 23320206 PMC: 3534206. DOI: 10.1155/2012/529730.

Pathologic and clinical features of pituitary adenomas showing TSH immunoreactivity.

Tritos N, Eppakayala S, Swearingen B, Hedley-Whyte E, Miller K, Nachtigall L Pituitary. 2012; 16(3):287-93.

PMID: 22869255 DOI: 10.1007/s11102-012-0419-3.

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