Outbreak of an Acute Aflatoxicosis in Kenya in 2004: Identification of the Causal Agent

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 2007 Feb 20

PMID 17308181

Citations 93

Authors

Claudia Probst

Henry Njapau

Peter J Cotty

Affiliations

Soon will be listed here.

Abstract

Maize contaminated with aflatoxins has been implicated in deadly epidemics in Kenya three times since 1981, but the fungi contaminating the maize with aflatoxins have not been characterized. Here we associate the S strain of Aspergillus flavus with lethal aflatoxicoses that took more than 125 lives in 2004.

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References

Ehrlich K, Chang P, Yu J, Cotty P . Aflatoxin biosynthesis cluster gene cypA is required for G aflatoxin formation. Appl Environ Microbiol. 2004; 70(11):6518-24. PMC: 525170. DOI: 10.1128/AEM.70.11.6518-6524.2004. View

Muture B, Ogana G . Aflatoxin levels in maize and maize products during the 2004 food poisoning outbreak in Eastern Province of Kenya. East Afr Med J. 2005; 82(6):275-9. DOI: 10.4314/eamj.v82i6.9296. View

Lewis L, Onsongo M, Njapau H, Schurz-Rogers H, Luber G, Kieszak S . Aflatoxin contamination of commercial maize products during an outbreak of acute aflatoxicosis in eastern and central Kenya. Environ Health Perspect. 2005; 113(12):1763-7. PMC: 1314917. DOI: 10.1289/ehp.7998. View

Jaime-Garcia R, Cotty P . Spatial Relationships of Soil Texture and Crop Rotation to Aspergillus flavus Community Structure in South Texas. Phytopathology. 2008; 96(6):599-607. DOI: 10.1094/PHYTO-96-0599. View

Cotty P . Comparison of four media for the isolation of Aspergillus flavus group fungi. Mycopathologia. 1994; 125(3):157-62. DOI: 10.1007/BF01146521. View

Jaime-Garcia R, Cotty P . Aspergillus flavus in Soils and Corncobs in South Texas: Implications for Management of Aflatoxins in Corn-Cotton Rotations. Plant Dis. 2019; 88(12):1366-1371. DOI: 10.1094/PDIS.2004.88.12.1366. View

Williams J, Phillips T, Jolly P, Stiles J, Jolly C, Aggarwal D . Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. Am J Clin Nutr. 2004; 80(5):1106-22. DOI: 10.1093/ajcn/80.5.1106. View

Garber R, Cotty P . Formation of Sclerotia and Aflatoxins in Developing Cotton Bolls Infected by the S Strain of Aspergillus flavus and Potential for Biocontrol with an Atoxigenic Strain. Phytopathology. 2008; 87(9):940-5. DOI: 10.1094/PHYTO.1997.87.9.940. View

. Outbreak of aflatoxin poisoning--eastern and central provinces, Kenya, January-July 2004. MMWR Morb Mortal Wkly Rep. 2004; 53(34):790-3. View

10.

Cardwell K, Cotty P . Distribution of Aspergillus Section Flavi among Field Soils from the Four Agroecological Zones of the Republic of Bénin, West Africa. Plant Dis. 2019; 86(4):434-439. DOI: 10.1094/PDIS.2002.86.4.434. View

11.

Cotty P, Cardwell K . Divergence of West African and North American communities of Aspergillus section Flavi. Appl Environ Microbiol. 1999; 65(5):2264-6. PMC: 91331. DOI: 10.1128/AEM.65.5.2264-2266.1999. View

12.

Ehrlich K, Yu J, Cotty P . Aflatoxin biosynthesis gene clusters and flanking regions. J Appl Microbiol. 2005; 99(3):518-27. DOI: 10.1111/j.1365-2672.2005.02637.x. View

13.

Bennett J, Klich M . Mycotoxins. Clin Microbiol Rev. 2003; 16(3):497-516. PMC: 164220. DOI: 10.1128/CMR.16.3.497-516.2003. View

14.

Brown R, Cotty P, Cleveland T, Widstrom N . Living Maize Embryo Influences Accumulation of Aflatoxin in Maize Kernels. J Food Prot. 2019; 56(11):967-971. DOI: 10.4315/0362-028X-56.11.967. View

15.

Azziz-Baumgartner E, Lindblade K, Gieseker K, Rogers H, Kieszak S, Njapau H . Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004. Environ Health Perspect. 2005; 113(12):1779-83. PMC: 1314920. DOI: 10.1289/ehp.8384. View

16.

Mateles R, ADYE J . PRODUCTION OF AFLATOXINS IN SUBMERGED CULTURE. Appl Microbiol. 1965; 13:208-11. PMC: 1058222. DOI: 10.1128/am.13.2.208-211.1965. View

17.

Novas M, Cabral D . Association of Mycotoxin and Sclerotia Production with Compatibility Groups in Aspergillus flavus from Peanut in Argentina. Plant Dis. 2019; 86(3):215-219. DOI: 10.1094/PDIS.2002.86.3.215. View