Skeletal Measurements by Quantitative Ultrasound in Adolescents and Young Women with Anorexia Nervosa

Overview

Journal J Pediatr

Specialty Pediatrics

Date 2007 Feb 20

PMID 17307548

Citations 2

Authors

Amy D DiVasta

Julie Ringelheim

Stephanie K Bristol

Henry A Feldman

Catherine M Gordon

Affiliations

Soon will be listed here.

Abstract

Objective: To compare quantitative ultrasound (QUS) measurements in adolescents with anorexia nervosa (AN) with that in healthy control subjects and to determine the utility of QUS as a tool to evaluate skeletal status in these patients.

Study Design: Female adolescents with AN (n = 41) and healthy control subjects (n = 105) were recruited. Speed of sound (SOS) was measured at the radius and tibia. Participants with AN also had hip and spinal areal bone mineral density measurements by dual-energy x-ray absorptiometry (DXA); bone mineral apparent density (BMAD) was calculated.

Results: Subjects with AN had higher mean radial SOS (4044 +/- 99 m/s) than did control subjects (3947 +/- 116 m/s; P < .0001). These results were replicated at the tibia (AN, 3918 +/- 85 m/s vs control subjects, 3827 +/- 106 m/s; P < .0001). Neither DXA measures of areal bone mineral density nor BMAD were correlated with SOS. Weight and body mass index were negative predictors of tibial but not radial SOS. AN status remained a significant predictor of SOS after controlling for body mass index, age, and race.

Conclusions: Subjects with AN had higher mean tibial and radial SOS than did control subjects. QUS variables did not correlate with DXA measures, calculated BMAD, or anthropometric variables. QUS measurements of SOS do not appear to be appropriate for bone density screening in patients with AN.

Citing Articles

Bone metabolism in adolescents with anorexia nervosa.

Misra M, Klibanski A J Endocrinol Invest. 2011; 34(4):324-32.

PMID: 21301203 PMC: 3671890. DOI: 10.1007/BF03347094.

Distal radius in adolescent girls with anorexia nervosa: trabecular structure analysis with high-resolution flat-panel volume CT.

Bredella M, Misra M, Miller K, Madisch I, Sarwar A, Cheung A Radiology. 2008; 249(3):938-46.

PMID: 19011190 PMC: 2691811. DOI: 10.1148/radiol.2492080173.

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