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What's Wrong with My Mouse Model? Advances and Strategies in Animal Modeling of Anxiety and Depression

Overview
Journal Behav Brain Res
Date 2007 Feb 20
PMID 17306892
Citations 88
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Abstract

Stress plays a key role in pathogenesis of anxiety and depression. Animal models of these disorders are widely used in behavioral neuroscience to explore stress-evoked brain abnormalities, screen anxiolytic/antidepressant drugs and establish behavioral phenotypes of gene-targeted or transgenic animals. Here we discuss the current situation with these experimental models, and critically evaluate the state of the art in this field. Noting a deficit of fresh ideas and especially new paradigms for animal anxiety and depression models, we review existing challenges and outline important directions for further research in this field.

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