Maintenance of Motor Neuron Progenitors in Xenopus Requires a Novel Localized Cyclin

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2007 Feb 17

PMID 17304238

Citations 9

Authors

Jun-An Chen

Sin-Tak Chu

Enrique Amaya

Affiliations

Soon will be listed here.

Abstract

The ventral spinal cord contains a pool of motor neuron progenitors (pMNs), which sequentially generate motor neurons and oligodendrocytes in the embryo. The mechanisms responsible for the maintenance of pMNs are not clearly understood. We have identified a novel cyclin, cyclin Dx (ccndx), which is specifically expressed in pMNs in Xenopus. Here, we show that inhibition of ccndx causes paralysis in embryos. Furthermore, we show that maintenance of pMNs requires ccndx function. In addition, inhibition of ccndx results in the specific loss of differentiated motor neurons. However, the expression of interneuron or sensory neuron markers is unaffected in these embryos, suggesting that the role of ccndx is specifically to maintain pMNs. Thus, we have identified, for the first time, a tissue-specific cell-cycle regulator that is essential for the maintenance of a pool of neural progenitors in the vertebrate spinal cord.

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