Caucasian Genes in American Blacks: New Data

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1992 Jan 1

PMID 1729885

Citations 66

Authors

R Chakraborty

M I Kamboh

M Nwankwo

R E Ferrell

Affiliations

Soon will be listed here.

Abstract

Data on 15 polymorphic protein-coding loci are used to estimate the proportion of Caucasian genes in U.S. blacks from the greater-metropolitan area of Pittsburgh. Allele frequencies from U.S. whites of the same region and from a sample of Nigerians are used as representatives of the genetic contributions of the source populations between which admixture has occurred. These materials provide 18 unique variants that occur exclusively in the blacks and 5 variants that are restricted to the Caucasians only. As a result, when all segregating alleles (52) at these 15 loci are considered, the proportion (mean +/- SE) of Caucasian genes in U.S. blacks (25.2% +/- 2.7%) is estimated with a precision much better than that of all other previous estimates. The estimate based on the frequencies of these 18 unique variants of African origin (24.8% +/- 6.2%) is also consistent with the pooled estimate obtained from the 15 loci by the weighted least-square method. The homogeneity of locus-specific estimates of admixture indicates that these loci are appropriate for studying the proportion of black genes in any admixed population involving African admixture. The advantages of employing such loci for genetic-epidemiologic studies in U.S. blacks is discussed in the context of the availability of these large number of unique African variants at these protein loci.

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References

Reed T . Caucasian genes in American Negroes. Science. 1969; 165(3895):762-8. DOI: 10.1126/science.165.3895.762. View

KAMINER B, LUTZ W . Blood pressure in Bushmen of the Kalahari Desert. Circulation. 1960; 22:289-95. DOI: 10.1161/01.cir.22.2.289. View

Glass B . On the unlikelihood of significant admixture of genes from the North American Indians in the present composition of the Negroes of the United States. Am J Hum Genet. 1955; 7(4):368-85. PMC: 1716681. View

Roberts D . The dynamics of racial intermixture in the American Negro-some anthropological considerations. Am J Hum Genet. 1955; 7(4):361-7. PMC: 1716669. View

ABRAHAMS D, ALELE C, BARNARD B . The systemic blood pressure in a rural West African community. West Afr Med J. 1960; 9:45-58. View

Chakraborty R, Kamboh M, Ferrell R . 'Unique' alleles in admixed populations: a strategy for determining 'hereditary' population differences of disease frequencies. Ethn Dis. 1991; 1(3):245-56. View

Long J . The genetic structure of admixed populations. Genetics. 1991; 127(2):417-28. PMC: 1204369. DOI: 10.1093/genetics/127.2.417. View

Kamboh M, Lyons L, Ferrell R . Genetic studies of low-abundance human plasma proteins. XIII. Population genetics of C1R complement subcomponent and description of new variants. Am J Hum Genet. 1989; 44(1):148-53. PMC: 1715479. View

Kamboh M, Albers J, Majumder P, Ferrell R . Genetic studies of human apolipoproteins. IX. Apolipoprotein D polymorphism and its relation to serum lipoprotein lipid levels. Am J Hum Genet. 1989; 45(1):147-54. PMC: 1683387. View

10.

Adams-Campbell L, Nwankwo M, Omene J, Ukoli F, Young M, Haile G . Assessment of cardiovascular risk factors in Nigerian students. Arteriosclerosis. 1988; 8(6):793-6. DOI: 10.1161/01.atv.8.6.793. View

11.

Kamboh M, Ferrell R . Ethnic variation in vitamin D-binding protein (GC): a review of isoelectric focusing studies in human populations. Hum Genet. 1986; 72(4):281-93. DOI: 10.1007/BF00290950. View

12.

Williams R, Steinberg A, Knowler W, Pettitt D . Gm 3;5,13,14 and stated-admixture: independent estimates of admixture in American Indians. Am J Hum Genet. 1986; 39(3):409-13. PMC: 1683959. View

13.

Escallon M, Ferrell R, Kamboh M . Genetic studies of low-abundance human plasma proteins. V. Evidence for a second orosomucoid structural locus (ORM2) expressed in plasma. Am J Hum Genet. 1987; 41(3):418-27. PMC: 1684184. View

14.

Chakraborty R, Ferrell R, Stern M, Haffner S, Hazuda H, Rosenthal M . Relationship of prevalence of non-insulin-dependent diabetes mellitus to Amerindian admixture in the Mexican Americans of San Antonio, Texas. Genet Epidemiol. 1986; 3(6):435-54. DOI: 10.1002/gepi.1370030608. View

15.

Chakraborty R, Weiss K . Frequencies of complex diseases in hybrid populations. Am J Phys Anthropol. 1986; 70(4):489-503. DOI: 10.1002/ajpa.1330700408. View

16.

Hanis C, Chakraborty R, Ferrell R, Schull W . Individual admixture estimates: disease associations and individual risk of diabetes and gallbladder disease among Mexican-Americans in Starr County, Texas. Am J Phys Anthropol. 1986; 70(4):433-41. DOI: 10.1002/ajpa.1330700404. View

17.

Bunker C, Nwankwo M, Ukoli F, Omene J, Currier G, Holifield L . Factors related to blood pressure among urban Nigerian workers. J Hum Hypertens. 1990; 4(2):82-4. View

18.

Long J, Smouse P . Intertribal gene flow between the Ye'cuana and Yanomama: genetic analysis of an admixed village. Am J Phys Anthropol. 1983; 61(4):411-22. DOI: 10.1002/ajpa.1330610403. View

19.

Byard P, Schanfield M, Crawford M . Admixture and heterozygosity in West Alaskan populations. J Biosoc Sci. 1983; 15(2):207-16. DOI: 10.1017/s0021932000014498. View

20.

Dischinger P, Apostolides A, ENTWISLE G, Hebel J . Hypertension incidence in an inner-city black population. J Chronic Dis. 1981; 34(8):405-13. DOI: 10.1016/0021-9681(81)90039-4. View