Coinfection with Schistosoma Mansoni Reactivates Viremia in Rhesus Macaques with Chronic Simian-human Immunodeficiency Virus Clade C Infection

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2007 Feb 7

PMID 17283092

Citations 24

Authors

Mila Ayash-Rashkovsky

Agnes-Laurence Chenine

Lisa N Steele

Sandra J Lee

Ruijiang Song

Helena Ong

Robert A Rasmussen

Regina Hofmann-Lehmann

James G Else

Peter Augostini

Harold M McClure

W Evan Secor

Ruth M Ruprecht

Affiliations

Soon will be listed here.

Abstract

We tested the hypothesis that helminth parasite coinfection would intensify viremia and accelerate disease progression in monkeys chronically infected with an R5 simian-human immunodeficiency virus (SHIV) encoding a human immunodeficiency virus type 1 (HIV-1) clade C envelope. Fifteen rhesus monkeys with stable SHIV-1157ip infection were enrolled into a prospective, randomized trial. These seropositive animals had undetectable viral RNA and no signs of immunodeficiency. Seven animals served as virus-only controls; eight animals were exposed to Schistosoma mansoni cercariae. From week 5 after parasite exposure onward, coinfected animals shed eggs in their feces, developed eosinophilia, and had significantly higher mRNA expression of the T-helper type 2 cytokine interleukin-4 (P = 0.001) than animals without schistosomiasis. Compared to virus-only controls, viral replication was significantly increased in coinfected monkeys (P = 0.012), and the percentage of their CD4(+) CD29(+) memory cells decreased over time (P = 0.05). Thus, S. mansoni coinfection significantly increased viral replication and induced T-cell subset alterations in monkeys with chronic SHIV clade C infection.

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