Estimation and Removal of Physiological Noise from Undersampled Multi-slice FMRI Data in Image Space

The signal variations induced by respiration and cardiac motion decrease the statistical significance in functional MRI data analysis. Significant components of these fluctuations are aliased into the activation spectrum in standard multi-slice imaging protocols. A method of estimation and removal physiological noise in image space is reported. Based on reordering the data from slice ordering to time ordering, the aliased physiological information is available in multi-slice magnitude images. Then physiological noise can be estimated and removed adaptively using signal projecting technique with the actual functional signal preserved.