Lipoprotein Receptors and Genetic Control of Cholesterol Metabolism in Cultured Human Cells

Overview

Journal Naturwissenschaften

Specialty Science

Date 1975 Aug 1

PMID 172803

Citations 5

Authors

M S Brown

J L Goldstein

Affiliations

Soon will be listed here.

Abstract

Biochemical analysis of cultured fibroblasts obtained from human subjects with the autosomal dominant disorder familial hypercholesterolemia has led to the identification of a hitherto unrecognized cell-surface receptor for serum lipoproteins. This receptor plays a critical role in the physiologic regulation of cholesterol metabolism in human cells, and its absence leads to elevation of serum-cholesterol levels and severe atheroslerosis.

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Interaction between fibroblasts, lipoproteins and three antilipoproteins IgA kappa.

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References

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Brown M, Dana S, Goldstein J . Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. J Biol Chem. 1974; 249(3):789-96. View

Brown M, Goldstein J . Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man. Science. 1974; 185(4145):61-3. DOI: 10.1126/science.185.4145.61. View

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Brown M, Dana S, Goldstein J . Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins. Proc Natl Acad Sci U S A. 1973; 70(7):2162-6. PMC: 433688. DOI: 10.1073/pnas.70.7.2162. View

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