Hematopoietic Stem Cell Aging: Mechanism and Consequence

Overview

Journal Exp Gerontol

Specialty Geriatrics

Date 2007 Feb 6

PMID 17275237

Citations 62

Authors

Derrick J Rossi

David Bryder

Irving L Weissman

Affiliations

Soon will be listed here.

Abstract

Advancing age is frequented by the onset of a variety of hematological conditions characterized by diminished homeostatic control of blood cell production. The fact that upstream hematopoietic stem and progenitor cells are obligate mediators of homeostatic control of all blood lineages, has implicated the involvement of these cells in the pathophysiology of these conditions. Indeed, evidence from our group and others has suggested that two of the most clinically significant age-associated hematological conditions, namely, the diminution of the adaptive immune system and the elevated incidence of myeloproliferative diseases, have their origin in cell autonomous changes in the functional capacity of hematopoietic stem cells.

Citing Articles

SARS-CoV-2 pseudovirus dysregulates hematopoiesis and induces inflammaging of hematopoietic stem and progenitor cells.

Chae D, Park H, Kim K, Yu A, Park J, Oh M Exp Mol Med. 2025; .

PMID: 40025168 DOI: 10.1038/s12276-025-01416-1.

Genetic enhancement: an avenue to combat aging-related diseases.

Cai Y, Ji Z, Wang S, Zhang W, Qu J, Belmonte J Life Med. 2025; 1(3):307-318.

PMID: 39872744 PMC: 11749557. DOI: 10.1093/lifemedi/lnac054.

Epidermal growth factor augments the self-renewal capacity of aged hematopoietic stem cells.

Chang V, He Y, Grohe S, Brady M, Chan A, Kadam R iScience. 2024; 27(7):110306.

PMID: 39055915 PMC: 11269946. DOI: 10.1016/j.isci.2024.110306.

Presepsin is a more useful predictor of septic AKI and ARDS for very-old sepsis patients than for young sepsis patients in ICUs: a pilot study.

Shimoyama Y, Kadono N, Umegaki O BMC Res Notes. 2024; 17(1):53.

PMID: 38378647 PMC: 10877906. DOI: 10.1186/s13104-024-06719-6.

Osteoblastic Wls Ablation Protects Mice from Total Body Irradiation-Induced Impairments in Hematopoiesis and Bone Marrow Microenvironment.

Sim H, So H, Poudel S, Bhattarai G, Cho E, Lee J Aging Dis. 2023; 14(3):919-936.

PMID: 37191410 PMC: 10187694. DOI: 10.14336/AD.2022.1026.

References

Kondo M, Weissman I, Akashi K . Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 1997; 91(5):661-72. DOI: 10.1016/s0092-8674(00)80453-5. View

Hu M, Krause D, Greaves M, Sharkis S, Dexter M, Heyworth C . Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 1997; 11(6):774-85. DOI: 10.1101/gad.11.6.774. View

Spilianakis C, Lalioti M, Town T, Lee G, Flavell R . Interchromosomal associations between alternatively expressed loci. Nature. 2005; 435(7042):637-45. DOI: 10.1038/nature03574. View

Rossi D, Bryder D, Zahn J, Ahlenius H, Sonu R, Wagers A . Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A. 2005; 102(26):9194-9. PMC: 1153718. DOI: 10.1073/pnas.0503280102. View

Kiel M, Yilmaz O, Iwashita T, Yilmaz O, Terhorst C, Morrison S . SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. 2005; 121(7):1109-21. DOI: 10.1016/j.cell.2005.05.026. View

Ling J, Li T, Hu J, Vu T, Chen H, Qiu X . CTCF mediates interchromosomal colocalization between Igf2/H19 and Wsb1/Nf1. Science. 2006; 312(5771):269-72. DOI: 10.1126/science.1123191. View

Bhattacharya D, Bryder D, Rossi D, Weissman I . Rapid lymphocyte reconstitution of unconditioned immunodeficient mice with non-self-renewing multipotent hematopoietic progenitors. Cell Cycle. 2006; 5(11):1135-9. PMC: 4507427. DOI: 10.4161/cc.5.11.2772. View

Bryder D, Rossi D, Weissman I . Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol. 2006; 169(2):338-46. PMC: 1698791. DOI: 10.2353/ajpath.2006.060312. View

Weissman I . Stem cells: units of development, units of regeneration, and units in evolution. Cell. 2000; 100(1):157-68. DOI: 10.1016/s0092-8674(00)81692-x. View

10.

Akashi K, Traver D, Miyamoto T, Weissman I . A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000; 404(6774):193-7. DOI: 10.1038/35004599. View

11.

Phillips R, Ernst R, Brunk B, Ivanova N, Mahan M, Deanehan J . The genetic program of hematopoietic stem cells. Science. 2000; 288(5471):1635-40. DOI: 10.1126/science.288.5471.1635. View

12.

Sudo K, Ema H, Morita Y, Nakauchi H . Age-associated characteristics of murine hematopoietic stem cells. J Exp Med. 2000; 192(9):1273-80. PMC: 2193349. DOI: 10.1084/jem.192.9.1273. View

13.

Adolfsson J, Borge O, Bryder D, Theilgaard-Monch K, Sitnicka E, Sasaki Y . Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity. 2001; 15(4):659-69. DOI: 10.1016/s1074-7613(01)00220-5. View

14.

Christensen J, Weissman I . Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci U S A. 2001; 98(25):14541-6. PMC: 64718. DOI: 10.1073/pnas.261562798. View

15.

Miyamoto T, Iwasaki H, Reizis B, Ye M, Graf T, Weissman I . Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell. 2002; 3(1):137-47. DOI: 10.1016/s1534-5807(02)00201-0. View

16.

Akashi K, He X, Chen J, Iwasaki H, Niu C, Steenhard B . Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood. 2002; 101(2):383-9. DOI: 10.1182/blood-2002-06-1780. View

17.

Chaudhuri J, Alt F . Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol. 2004; 4(7):541-52. DOI: 10.1038/nri1395. View

18.

Spangrude G, Heimfeld S, Weissman I . Purification and characterization of mouse hematopoietic stem cells. Science. 1988; 241(4861):58-62. DOI: 10.1126/science.2898810. View

19.

Ikuta K, Weissman I . Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci U S A. 1992; 89(4):1502-6. PMC: 48479. DOI: 10.1073/pnas.89.4.1502. View

20.

Li C, Johnson G . Murine hematopoietic stem and progenitor cells: I. Enrichment and biologic characterization. Blood. 1995; 85(6):1472-9. View