FMRI Analysis for Motor Paradigms Using EMG-based Designs: a Validation Study

Overview

Journal Hum Brain Mapp

Publisher Wiley

Specialty Neurology

Date 2007 Feb 3

PMID 17274019

Citations 14

Authors

Anne-Fleur van Rootselaar

Remco Renken

Bauke M de Jong

Johannes M Hoogduin

Marina A J Tijssen

Natasha M Maurits

Affiliations

Soon will be listed here.

Abstract

The goal of the present validation study is to show that continuous surface EMG recorded simultaneously with 3T fMRI can be used to identify local brain activity related to (1) motor tasks, and to (2) muscle activity independently of a specific motor task, i.e. spontaneous (abnormal) movements. Five healthy participants performed a motor task, consisting of posture (low EMG power), and slow (medium EMG power) and fast (high EMG power) wrist flexion-extension movements. Brain activation maps derived from a conventional block design analysis (block-only design) were compared with brain activation maps derived using EMG-based regressors: (1) using the continuous EMG power as a single regressor of interest (EMG-only design) to relate motor performance and brain activity, and (2) using EMG power variability as an additional regressor in the fMRI block design analysis to relate movement variability and brain activity (mathematically) independent of the motor task. The agreement between the identified brain areas for the block-only design and the EMG-only design was excellent for all participants. Additionally, we showed that EMG power variability correlated well with activity in brain areas known to be involved in movement modulation. These innovative EMG-fMRI analysis techniques will allow the application of novel motor paradigms. This is an important step forward in the study of both the normally functioning motor system and the pathophysiological mechanisms in movement disorders.

Citing Articles

Development of a trunk motor paradigm for use in neuroimaging.

Saunders E, Clark B, Clark L, Grooms D Transl Neurosci. 2020; 11(1):193-200.

PMID: 33335758 PMC: 7712160. DOI: 10.1515/tnsci-2020-0116.

Familial Cortical Myoclonic Tremor and Epilepsy, an Enigmatic Disorder: From Phenotypes to Pathophysiology and Genetics. A Systematic Review.

Ende T, Sharifi S, van der Salm S, van Rootselaar A Tremor Other Hyperkinet Mov (N Y). 2018; 8:503.

PMID: 29416935 PMC: 5801339. DOI: 10.7916/D85155WJ.

Decoding fMRI events in sensorimotor motor network using sparse paradigm free mapping and activation likelihood estimates.

Tan F, Caballero-Gaudes C, Mullinger K, Cho S, Zhang Y, Dryden I Hum Brain Mapp. 2017; 38(11):5778-5794.

PMID: 28815863 PMC: 5632561. DOI: 10.1002/hbm.23767.

Bilateral cerebellar activation in unilaterally challenged essential tremor.

Broersma M, van der Stouwe A, Buijink A, de Jong B, Groot P, Speelman J Neuroimage Clin. 2016; 11:1-9.

PMID: 26909321 PMC: 4732188. DOI: 10.1016/j.nicl.2015.12.011.

Neuroimaging essentials in essential tremor: a systematic review.

Sharifi S, Nederveen A, Booij J, van Rootselaar A Neuroimage Clin. 2014; 5:217-31.

PMID: 25068111 PMC: 4110352. DOI: 10.1016/j.nicl.2014.05.003.

References

Toma K, Honda M, Hanakawa T, Okada T, Fukuyama H, Ikeda A . Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: an event-related fMRI study. J Neurosci. 1999; 19(9):3527-34. PMC: 6782247. View

Liu J, Zhang L, Brown R, Yue G . Reproducibility of fMRI at 1.5 T in a strictly controlled motor task. Magn Reson Med. 2004; 52(4):751-60. DOI: 10.1002/mrm.20211. View

van Duinen H, Zijdewind I, Hoogduin H, Maurits N . Surface EMG measurements during fMRI at 3T: accurate EMG recordings after artifact correction. Neuroimage. 2005; 27(1):240-6. DOI: 10.1016/j.neuroimage.2005.04.003. View

Liu J, Dai T, Elster T, Sahgal V, Brown R, Yue G . Simultaneous measurement of human joint force, surface electromyograms, and functional MRI-measured brain activation. J Neurosci Methods. 2000; 101(1):49-57. DOI: 10.1016/s0165-0270(00)00252-1. View

Oga T, Honda M, Toma K, Murase N, Okada T, Hanakawa T . Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer's cramp: an fMRI study. Brain. 2002; 125(Pt 4):895-903. DOI: 10.1093/brain/awf083. View

MacIntosh B, Mraz R, Baker N, Tam F, Staines W, Graham S . Optimizing the experimental design for ankle dorsiflexion fMRI. Neuroimage. 2004; 22(4):1619-27. DOI: 10.1016/j.neuroimage.2004.03.035. View

Dai T, Liu J, Sahgal V, Brown R, Yue G . Relationship between muscle output and functional MRI-measured brain activation. Exp Brain Res. 2001; 140(3):290-300. DOI: 10.1007/s002210100815. View

Lemieux L, Allen P, Franconi F, Symms M, Fish D . Recording of EEG during fMRI experiments: patient safety. Magn Reson Med. 1997; 38(6):943-52. DOI: 10.1002/mrm.1910380614. View

Allen P, Josephs O, Turner R . A method for removing imaging artifact from continuous EEG recorded during functional MRI. Neuroimage. 2000; 12(2):230-9. DOI: 10.1006/nimg.2000.0599. View

10.

Liu J, Shan Z, Zhang L, Sahgal V, Brown R, Yue G . Human brain activation during sustained and intermittent submaximal fatigue muscle contractions: an FMRI study. J Neurophysiol. 2003; 90(1):300-12. DOI: 10.1152/jn.00821.2002. View

11.

Goldman R, Stern J, Engel Jr J, Cohen M . Simultaneous EEG and fMRI of the alpha rhythm. Neuroreport. 2002; 13(18):2487-92. PMC: 3351136. DOI: 10.1097/01.wnr.0000047685.08940.d0. View

12.

Liu J, Zhang L, Yao B, Yue G . Accessory hardware for neuromuscular measurements during functional MRI experiments. MAGMA. 2002; 13(3):164-71. DOI: 10.1007/BF02678592. View

13.

Liu J, Dai T, Sahgal V, Brown R, Yue G . Nonlinear cortical modulation of muscle fatigue: a functional MRI study. Brain Res. 2002; 957(2):320-9. DOI: 10.1016/s0006-8993(02)03665-x. View

14.

Laufs H, Krakow K, Sterzer P, Eger E, Beyerle A, Salek-Haddadi A . Electroencephalographic signatures of attentional and cognitive default modes in spontaneous brain activity fluctuations at rest. Proc Natl Acad Sci U S A. 2003; 100(19):11053-8. PMC: 196925. DOI: 10.1073/pnas.1831638100. View

15.

Myers L, Lowery M, OMalley M, Vaughan C, Heneghan C, St Clair Gibson A . Rectification and non-linear pre-processing of EMG signals for cortico-muscular analysis. J Neurosci Methods. 2003; 124(2):157-65. DOI: 10.1016/s0165-0270(03)00004-9. View

16.

Feige B, Scheffler K, Esposito F, di Salle F, Hennig J, Seifritz E . Cortical and subcortical correlates of electroencephalographic alpha rhythm modulation. J Neurophysiol. 2004; 93(5):2864-72. DOI: 10.1152/jn.00721.2004. View

17.

OLDFIELD R . The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971; 9(1):97-113. DOI: 10.1016/0028-3932(71)90067-4. View