Polymorphic Variation in Human Meiotic Recombination

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 2007 Feb 3

PMID 17273974

Citations 40

Authors

Vivian G Cheung

Joshua T Burdick

Deborah Hirschmann

Michael Morley

Affiliations

Soon will be listed here.

Abstract

In this study, our phenotype of interest is meiotic recombination. Using genotypes of approximately 6,000 SNP markers in members of the Centre d'Etude du Polymorphisme Humain Utah pedigrees, we found extensive individual variation in the number of female and male recombination events. The locations and frequencies of these recombination events vary along the genome. In both female and male meiosis, the regions with the most recombination events are found at the ends of the chromosomes. Our analysis also shows that there are polymorphic differences among individuals in the activity of the recombination "jungles"; these preferred sites of meiotic recombination differ greatly among individuals. These findings have important implications for understanding genetic disorders that result from improper chromosome segregation.

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