Metastases from Renal Cell Carcinoma Presenting As Gastrointestinal Bleeding: Two Case Reports and a Review of the Literature

Overview

Journal BMC Gastroenterol

Publisher Biomed Central

Specialty Gastroenterology

Date 2007 Feb 3

PMID 17266757

Citations 36

Authors

Gareth J Sadler

Mark R Anderson

Mark S Moss

Paul G Wilson

Affiliations

Soon will be listed here.

Abstract

Background: Bleeding from small bowel neoplasms account for 1-4% of cases of upper gastrointestinal haemorrhage. Renal cell carcinoma constitutes 3% of all adult malignancies and often presents insidiously. Consequently 25-30% of patients have metastases at the time of diagnosis. Gastrointestinal bleeding from renal cell carcinoma metastases is an uncommon and under-recognised manifestation of this disease.

Case Report: In this report we describe two cases of gastrointestinal bleeding from renal cell carcinoma metastases - in one patient bleeding heralded the primary manifestation of disease and in the other signified recurrence of disease following nephrectomy.

Conclusion: These cases highlight the importance endoscopic vigilance in cases of undiagnosed upper gastrointestinal haemorrhage, especially in patients with a past history of renal cell carcinoma.

Citing Articles

Vulvar Metastasis in Renal Cell Carcinoma: A Case Report Highlighting the Aggressive Nature of Clear Cell Renal Cell Carcinoma.

Boiangiu A, Cioca A, Gorecki G, Sima R, Ples L, Novac M Curr Oncol. 2025; 32(1).

PMID: 39851920 PMC: 11763611. DOI: 10.3390/curroncol32010004.

Renal Cell Carcinoma Masquerading as Acute Upper Gastrointestinal Bleeding.

Rayamajhi A, Agrawal S, Rayamajhi S, Lamsal M, Koirala D Case Rep Med. 2024; 2024:7122744.

PMID: 39474261 PMC: 11519071. DOI: 10.1155/2024/7122744.

An unusual metastatic site of renal cell carcinoma: A case report.

Benbrahim F, Ankri M, Zebbakh H, Essaber H, Bakkari A, Allioui S Urol Case Rep. 2024; 55:102777.

PMID: 39036286 PMC: 11260032. DOI: 10.1016/j.eucr.2024.102777.

An Atypical Presentation of Metastatic Renal Cell Carcinoma.

Chowdhury S, Haque S, Sanekommu H, Nightingale B, Razi S, Hossain M J Med Cases. 2024; 15(7):126-129.

PMID: 38993809 PMC: 11236335. DOI: 10.14740/jmc4225.

Cecal Metastasis of Clear Cell Renal Cell Carcinoma After Previous Nephrectomy.

Lin R, Shen S, Donabedian P, Kiani C, Kresak J, Chatzkel J ACG Case Rep J. 2024; 11(5):e01352.

PMID: 38706450 PMC: 11068133. DOI: 10.14309/crj.0000000000001352.

References

Tuech J, Pessaux P, Chautard D, Rouge C, Binelli C, Bergamaschi R . Results of duodenopancreatectomy for solitary pancreatic metastasis from renal cell carcinoma. J Hepatobiliary Pancreat Surg. 2000; 6(4):396-8. DOI: 10.1007/s005340050138. View

Graham A . Malignancy of the kidney, survey of 195 cases. J Urol. 2010; 58(1):10-21. DOI: 10.1016/S0022-5347(17)69512-0. View

Deguchi R, Takagi A, Igarashi M, Shirai T, Shiba T, Watanabe S . A case of ileocolic intussusception from renal cell carcinoma. Endoscopy. 2000; 32(8):658-60. DOI: 10.1055/s-2000-4661. View

Faure J, Tuech J, Richer J, Pessaux P, Arnaud J, Carretier M . Pancreatic metastasis of renal cell carcinoma: presentation, treatment and survival. J Urol. 2000; 165(1):20-2. DOI: 10.1097/00005392-200101000-00005. View

Savoye-Collet C, Thoumas D, Dunet F, Lemercier E, Benozio M, Dacher J . CT diagnosed jejunal intussusception revealing metastatic renal cell carcinoma. JBR-BTR. 2001; 84(4):153-4. View

Lisii D, Gainant A, Sautereau D, Paraf F, Maubon A . [Duodenal bleeding revealing a renal cell carcinoma]. Gastroenterol Clin Biol. 2002; 26(11):1044-6. View

Pavlakis G, Sakorafas G, Anagnostopoulos G . Intestinal metastases from renal cell carcinoma: a rare cause of intestinal obstruction and bleeding. Mt Sinai J Med. 2004; 71(2):127-30. View

Chang W, Chai C, Lee K . Unusual upper gastrointestinal bleeding due to late metastasis from renal cell carcinoma: a case report. Kaohsiung J Med Sci. 2004; 20(3):137-41. DOI: 10.1016/S1607-551X(09)70098-1. View

Loualidi A, Spooren P, Grubben M, Blomjous C, Goey S . Duodenal metastasis: an uncommon cause of occult small intestinal bleeding. Neth J Med. 2004; 62(6):201-5. View

10.

Waters W, Richie J . Aggressive surgical approach to renal cell carcinoma: review of 130 cases. J Urol. 1979; 122(3):306-9. DOI: 10.1016/s0022-5347(17)56378-8. View

11.

Maldazys J, DeKernion J . Prognostic factors in metastatic renal carcinoma. J Urol. 1986; 136(2):376-9. DOI: 10.1016/s0022-5347(17)44873-7. View

12.

Haynes I, Wolverson R, OBrien J . Small bowel intussusception due to metastatic renal carcinoma. Br J Urol. 1986; 58(4):460. DOI: 10.1111/j.1464-410x.1986.tb09110.x. View

13.

Fishman E, Kadir S . Diagnosis and management of massive gastrointestinal bleeding owing to duodenal metastasis from renal cell carcinoma. J Urol. 1987; 138(3):611-3. DOI: 10.1016/s0022-5347(17)43275-7. View

14.

Ashley S, Wells Jr S . Tumors of the small intestine. Semin Oncol. 1988; 15(2):116-28. View

15.

Low D, Frenkel V, Manley P, Ford S, Kerr J . Embolic mesenteric infarction: a unique initial manifestation of renal cell carcinoma. Surgery. 1989; 106(5):925-8. View

16.

Short T, Thomas E, Joshi P, Martin A, Mullins R . Occult gastrointestinal bleeding in renal cell carcinoma: value of endoscopic evaluation. Am J Gastroenterol. 1993; 88(2):300-2. View

17.

Calmes J, Meyer A . [Pancreatic hypernephroma manifested by a duodenal hemorrhage]. Rev Med Suisse Romande. 1993; 113(8):629-31. View

18.

Black J, Mendelson R . Duodenal haemorrhage resulting from renal cell carcinoma metastases. Australas Radiol. 1995; 39(4):396-8. DOI: 10.1111/j.1440-1673.1995.tb00320.x. View

19.

Blake M, Owens A, ODonoghue D, MacErlean D . Embolotherapy for massive upper gastrointestinal haemorrhage secondary to metastatic renal cell carcinoma: report of three cases. Gut. 1995; 37(6):835-7. PMC: 1382948. DOI: 10.1136/gut.37.6.835. View

20.

Hirota T, Tomida T, Iwasa M, Takahashi K, Kaneda M, Tamaki H . Solitary pancreatic metastasis occurring eight years after nephrectomy for renal cell carcinoma. A case report and surgical review. Int J Pancreatol. 1996; 19(2):145-53. DOI: 10.1007/BF02805229. View