G Protein-coupled Receptors Control NMDARs and Metaplasticity in the Hippocampus

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2007 Jan 31

PMID 17261268

Citations 34

Authors

John F Macdonald

Michael F Jackson

Michael A Beazely

Affiliations

Soon will be listed here.

Abstract

Long-term potentiation (LTP) and long-term depression (LTD) are the major forms of functional synaptic plasticity observed at CA1 synapses of the hippocampus. The balance between LTP and LTD or "metaplasticity" is controlled by G-protein coupled receptors (GPCRs) whose signal pathways target the N-methyl-D-asparate (NMDA) subtype of excitatory glutamate receptor. We discuss the protein kinase signal cascades stimulated by Galphaq and Galphas coupled GPCRs and describe how control of NMDAR activity shifts the threshold for the induction of LTP.

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