Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation

Overview

Journal J Neurosci

Specialty Neurology

Date 2007 Jan 26

PMID 17251418

Citations 191

Authors

Joseph F Cheer

Kate M Wassum

Leslie A Sombers

Michael L A V Heien

Jennifer L Ariansen

Brandon J Aragona

Paul E M Phillips

R Mark Wightman

Affiliations

Soon will be listed here.

Abstract

Transient surges of dopamine in the nucleus accumbens are associated with drug seeking. Using a voltammetric sensor with high temporal and spatial resolution, we demonstrate differences in the temporal profile of dopamine concentration transients caused by acute doses of nicotine, ethanol, and cocaine in the nucleus accumbens shell of freely moving rats. Despite differential release dynamics, all drug effects are uniformly inhibited by administration of rimonabant, a cannabinoid receptor (CB1) antagonist, suggesting that an increase in endocannabinoid tone facilitates the effects of commonly abused drugs on subsecond dopamine release. These time-resolved chemical measurements provide unique insight into the neurobiological effectiveness of rimonabant in treating addictive disorders.

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