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Genetic Organization in CAENORHABDITIS ELEGANS: Fine-Structure Analysis of the Unc-22 Gene

Overview
Journal Genetics
Publisher Oxford University Press
Specialty Genetics
Date 1979 Jan 1
PMID 17248882
Citations 53
Authors
D G Moerman
D L Baillie
Affiliations
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Abstract

Fine-structure analysis of the unc-22 gene of Caenorhabditis elegans has revealed a number of sites that are separable by recombination. Eight new ethyl methanesulfonate-induced recessive mutations of the unc-22 gene have been isolated. Using these new alleles, as well as e66, a number of separable sites have been identified and positioned relative to one another. The map distances obtained are found to be comparable to those associated with intragenic recombination in Drosophila melanogaster, indicating that genetic fine-structure analysis is feasible in Caenorhabditis elegans. Evidence of possible gene conversion is presented. A preliminary estimate of the unc-22 gene size is 2.4 x 10(-2) map units.

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References
1.
Fogel S, MORTIMER R . Informational transfer in meiotic gene conversion. Proc Natl Acad Sci U S A. 1969; 62(1):96-103. PMC: 285960. DOI: 10.1073/pnas.62.1.96. View
2.
Duck P, Chovnick A . Resolution of an equivocal genetic element in Drosophila melanogaster: organization of the maroon-like locus. Genetics. 1975; 79(3):459-66. PMC: 1213285. DOI: 10.1093/genetics/79.3.459. View
3.
Gelbart W, McCarron M, Chovnick A . Extension of the limits of the XDH structural element in Drosophila melanogaster. Genetics. 1976; 84(2):211-32. PMC: 1213573. DOI: 10.1093/genetics/84.2.211. View
4.
Judd B . THE STRUCTURE OF INTRALOCUS DUPLICATION AND DEFICIENCY CHROMOSOMES PRODUCED BY RECOMBINATION IN DROSOPHILA MELANOGASTER, WITH EVIDENCE FOR POLARIZED PAIRING. Genetics. 1964; 49:253-65. PMC: 1210567. DOI: 10.1093/genetics/49.2.253. View
5.
Mitchell M . ABERRANT RECOMBINATION OF PYRIDOXINE MUTANTS OF Neurospora. Proc Natl Acad Sci U S A. 1955; 41(4):215-20. PMC: 528059. DOI: 10.1073/pnas.41.4.215. View