Oral Specific Desensitization in Food-allergic Children

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2007 Jan 25

PMID 17245630

Citations 34

Authors

Giampiero Patriarca

Eleonora Nucera

Emanuela Pollastrini

Chiara Roncallo

Tiziana De Pasquale

Carla Lombardo

Claudio Pedone

Giovanni Gasbarrini

Alessandro Buonomo

Domenico Schiavino

Affiliations

Soon will be listed here.

Abstract

The possibility of obtaining oral desensitization in patients with food allergy is still a matter of debate. We decided to evaluate the safety and efficacy of standardized protocols for oral desensitization with the most common food allergens. Forty-two children (ages up to 16 years) diagnosed as affected by food allergy (on the basis of clinical history, skin prick tests, measurement of specific IgE, and double-blind, placebo-controlled food challenge) underwent a sublingual-oral desensitizing treatment according to new standardized protocols. The control group consisted of 10 patients who followed an elimination diet. The treatment was successfully completed by 85.7% of the patients. Specific IgE showed a significant decrease, while specific IgG(4) showed a significant increase, in all treated patients. The immunological modifications observed in our patients lead us to hypothesize that oral tolerance may be mediated by the same mechanisms as those involved in traditional desensitizing treatments for respiratory and insect sting allergy.

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