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Palmitoylation-dependent Protein Sorting

Overview
Journal J Cell Biol
Specialty Cell Biology
Date 2007 Jan 24
PMID 17242068
Citations 139
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Abstract

S-palmitoylation is a posttranslational modification that regulates membrane-protein interactions. However, palmitate is more than just a hydrophobic membrane anchor, as many different types of protein are palmitoylated, including transmembrane proteins. Indeed, there is now compelling evidence that palmitoylation plays a key role in regulating various aspects of protein sorting within the cell.

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References
1.
El-Husseini A, Craven S, Chetkovich D, Firestein B, Schnell E, Aoki C . Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering. J Cell Biol. 2000; 148(1):159-72. PMC: 2156213. DOI: 10.1083/jcb.148.1.159. View

2.
Heino S, Lusa S, Somerharju P, Ehnholm C, Olkkonen V, Ikonen E . Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface. Proc Natl Acad Sci U S A. 2000; 97(15):8375-80. PMC: 26955. DOI: 10.1073/pnas.140218797. View

3.
Uittenbogaard A, Smart E . Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complex formation, and rapid transport of cholesterol to caveolae. J Biol Chem. 2000; 275(33):25595-9. DOI: 10.1074/jbc.M003401200. View

4.
Craven S, Brock S, Bredt D . Polarized targeting of peripheral membrane proteins in neurons. J Biol Chem. 2001; 276(48):44984-92. DOI: 10.1074/jbc.M103049200. View

5.
El-Husseini A, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O . Synaptic strength regulated by palmitate cycling on PSD-95. Cell. 2002; 108(6):849-63. DOI: 10.1016/s0092-8674(02)00683-9. View