Immunotherapy with Antibodies to Core Lipopolysaccharide: a Critical Appraisal
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The unknowns persisting in the understanding of the mode of action of anti-core lipopolysaccharide antibodies are discussed, and a study of two anti-lipid A monoclonal antibodies is reviewed. This article also critically analyzes the results of the recent clinical trials with monoclonal antibodies.
[Endotoxins. Pathogenetic meaning of sepsis].
Rensing H Anaesthesist. 2004; 52 Suppl 1:S7-S13.
PMID: 14727044 DOI: 10.1007/s00101-003-0587-7.
The economic impact of HA-1A (Centoxin) against endotoxin.
Barriere S Pharmacoeconomics. 1992; 2(5):408-13.
PMID: 10147053 DOI: 10.2165/00019053-199202050-00008.
Fc gamma receptor-dependent clearance is enhanced following lipopolysaccharide in vivo treatment.
Palermo M, Alves Rosa F, Fernandez Alonso G, Isturiz M Immunology. 1998; 92(4):536-43.
PMID: 9497496 PMC: 1364160. DOI: 10.1046/j.1365-2567.1997.00376.x.
Bailat S, Heumann D, Le Roy D, Baumgartner J, Rietschel E, Glauser M Infect Immun. 1997; 65(2):811-4.
PMID: 9009348 PMC: 176131. DOI: 10.1128/iai.65.2.811-814.1997.
Hoffman W, Danner R, Quezado Z, Banks S, Elin R, Hosseini J Infect Immun. 1996; 64(2):406-12.
PMID: 8550184 PMC: 173778. DOI: 10.1128/iai.64.2.406-412.1996.