Enhancing Skin Wound Healing by Direct Delivery of Intracellular Adenosine Triphosphate

Overview

Journal Am J Surg

Specialty General Surgery

Date 2007 Jan 24

PMID 17236849

Citations 27

Authors

Benjamin Chiang

Eric Essick

William Ehringer

Sidney Murphree

Mary Anne Hauck

Ming Li

Sufan Chien

Affiliations

Soon will be listed here.

Abstract

Background: A new intracellular adenosine triphosphate (ATP) delivery technique has been developed and was tested for skin wound care.

Methods: Eleven pairs of adult nude mice were used. ATP-vesicles were applied in 11 mice, and another 11 mice were treated with lipid vesicles only.

Results: The group treated with ATP-encapsulated fusogenic small, unilamellar lipid vesicles healed faster than the group treated with only lipid vesicles. Histologic study indicated better developed granular tissue and re-epithelialization in the study group, and wound tissue vascular endothelial growth factor expressions were also higher in ATP-vesicles treated mice.

Conclusions: This intracellular ATP delivery system may provide a new hope for wound healing as well as the treatment of medical conditions in which ischemia is involved.

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