Clinicopathological Significance of MMP-2 and TIMP-2 Genotypes in Gastric Cancer

Overview

Journal Eur J Cancer

Specialty Oncology

Date 2007 Jan 24

PMID 17236757

Citations 21

Authors

Chun-Ying Wu

Ming-Shiang Wu

Yi-Ju Chen

Chien-Jen Chen

Hsiao-Ping Chen

Chia-Tung Shun

Gran-Hum Chen

Shih-Pei Huang

Jaw-Town Lin

Affiliations

Soon will be listed here.

Abstract

Aims: Single nucleotide polymorphisms in matrix metalloproteinase-2 (MMP-2) -1306 C/T and tissue inhibitor of metalloproteinase-2 (TIMP-2) -418 G/C abolish the Sp-1 binding site and down-regulate expression of these genes. We aim to elucidate the role of MMP-2 and TIMP-2 in clinicopathological manifestations of gastric cancer.

Methods: We enrolled 240 gastric cancer patients and 283 controls. DNA was extracted from peripheral blood leucocytes. MMP-2 and TIMP-2 genotypes were analysed by PCR-direct sequencing and PCR-RFLP method, respectively.

Results: MMP-2 and TIMP-2 genotypes were not associated with gastric cancer development. However, patients with MMP-2 -1306 C/C genotype showed higher risk of lymphatic invasion (odds ratio (OR)=2.77, p=0.01) and venous invasion (OR=2.93, p=0.012). TIMP-2 G/G genotype was associated with serosal invasion (OR=1.89, p=0.009), lymph node metastasis (OR=2.19, p=0.021), lymphatic invasion (OR=2.87, p=0.016) and venous invasion (OR=2.65, p=0.033).

Conclusion: Our results suggest MMP-2 and TIMP-2 genotypes play a crucial role in gastric cancer invasion, but not with development of gastric cancer.

Citing Articles

TIMP-2 as a predictive biomarker in 5-Fu-resistant colorectal cancer.

Li Y, Xu C, Zhu R, Shen L, Hu G, Tao K J Cancer Res Clin Oncol. 2023; 149(10):7235-7246.

PMID: 36905423 DOI: 10.1007/s00432-023-04670-w.

Sec62 promotes gastric cancer metastasis through mediating UPR-induced autophagy activation.

Su S, Shi Y, Chu Y, Jiang M, Wu N, Xu B Cell Mol Life Sci. 2022; 79(2):133.

PMID: 35165763 PMC: 11073224. DOI: 10.1007/s00018-022-04143-2.

Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment.

Lu Y, Hsin C, Lu Y, Wu M, Huang J, Huang C Sci Rep. 2021; 11(1):6229.

PMID: 33737604 PMC: 7973765. DOI: 10.1038/s41598-021-85598-4.

Molecular Alterations in Metastatic Ovarian Cancer From Gastrointestinal Cancer.

Chen C, Ge X, Zhao Y, Wang D, Ling L, Zheng S Front Oncol. 2020; 10:605349.

PMID: 33363035 PMC: 7758447. DOI: 10.3389/fonc.2020.605349.

Oxymatrine inhibits the migration and invasion of hepatocellular carcinoma cells by reducing the activity of MMP-2/-9 via regulating p38 signaling pathway.

Chen K, Zhu P, Ye J, Liao Y, Du Z, Chen F J Cancer. 2019; 10(22):5397-5403.

PMID: 31632484 PMC: 6775708. DOI: 10.7150/jca.32875.