The Cationic Amino Acid Transporters CAT1 and CAT3 Mediate NMDA Receptor Activation-dependent Changes in Elaboration of Neuronal Processes Via the Mammalian Target of Rapamycin MTOR Pathway

Overview

Journal J Neurosci

Specialty Neurology

Date 2007 Jan 20

PMID 17234578

Citations 33

Authors

Yunfei Huang

Bingnan N Kang

Jing Tian

Yi Liu

Hongbo R Luo

Lynda Hester

Solomon H Snyder

Affiliations

Soon will be listed here.

Abstract

Neuronal activity influences protein synthesis and neuronal growth. Availability of nutrients, especially leucine and arginine, regulates the mammalian target of rapamycin (mTOR) pathway that controls cell growth. We show that NMDA receptor activation markedly reduces arginine transport by decreasing surface expression of the cationic amino acid transporters (CAT) 1 and 3. Depletion of CAT1 and CAT3 by RNA interference blocks influences of NMDA receptor activation on the mTOR pathway and neuronal process formation. Thus, the CATs mediate influences of NMDA receptor activation on the mTOR pathway that regulates neuronal processes.

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